Apixaban Impurity 99 CAS 1802522-36-6
| CAS No. | 1802522-36-6 |
| Molecular Formula | C10H16Cl2O3 |
| Molecular Weight | 255.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Apixaban Impurity 99 (CAS 1802522-36-6) is a certified pharmaceutical impurity reference standard with the molecular formula C10H16Cl2O3 and a molecular weight of 255.14 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Apixaban Impurity 99 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 255.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Apixaban Impurity 99 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H16Cl2O3 |
| Molecular Weight | 255.14 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
Related Apixaban Standards
- Apixaban Impurity 146 (CAS CATO-C4X-1088146)
- Apixaban Impurity 96 (CAS 2512213-45-3)
- Apixaban Impurity 110 (CAS 473927-63-8)
- Apixaban Impurity 14 (CAS 405872-78-8/2228998-99-8)
- Apixaban Impurity 18 (CAS 27143-07-3)
- Apixaban Impurity 36 (CAS 85014-68-2/2228050-22-2)
- Apixaban Impurity 64 (CAS 1039914-85-6)
- Apixaban Impurity 99 (CAS 22715-73-7)
Recommended Standards
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- 4-(Aminomethyl)-5-(difluoromethyl)-6-methoxynicotinonitrile (CAS 1806911-23-8)
- CAS 2260670-13-9 (CAS 2260670-13-9)
- Methyl 2-(4-(methoxymethyl)phenyl)acetate (CAS 115414-80-7)
- Ethyl 4-Methylbenzoylformate (CAS 5524-56-1)
- 3-Phenyl-2-propionylisoxazol-5(2H)-one (CAS 320423-43-6)
- Palonosetron Impurity 47 (CAS 2216746-63-1(free base))
- Tirzepatide Impurity 20 (CAS CATO-C4X-324020)
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