N-(2,2-difluoroethyl)-1-methanesulfonylpiperidin-4-amine hydrochloride CAS 1803581-08-9

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(2,2-difluoroethyl)-1-methanesulfonylpiperidin-4-amine hydrochloride.

CATO supplies N-(2,2-difluoroethyl)-1-methanesulfonylpiperidin-4-amine hydrochloride (CAS 1803581-08-9), a certified reference material (molecular formula C8H16F2N2O2SHCl, MW 278.74 g/mol) for analytical method development and quality control.

The molecular framework of N-(2,2-difluoroethyl)-1-methanesulfonylpiperidin-4-amine hydrochloride (C8H16F2N2O2SHCl) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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