2-(Chloromethyl)-5-hydroxybenzo[d]oxazole CAS 1803809-69-9
| CAS No. | 1803809-69-9 |
| Molecular Formula | C8H6ClNO2 |
| Molecular Weight | 183.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(Chloromethyl)-5-hydroxybenzo[d]oxazole is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(Chloromethyl)-5-hydroxybenzo[d]oxazole (CAS 1803809-69-9), molecular formula C8H6ClNO2 and molecular weight 183.59 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Chloromethyl)-5-hydroxybenzo[d]oxazole (C8H6ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6ClNO2 |
| Molecular Weight | 183.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
- 2-(chloromethyl)-1,3-benzoxazol-6-ol (CAS 136535-21-2)
- 6-(Chloromethyl)pyridine-2,4-dicarbaldehyde (CAS 1393550-18-9)
- 4-(chloromethyl)-5-(furan-2-yl)-1,2-oxazole (CAS 1423033-19-5)
- 2-(Chloromethyl)-7-hydroxybenzo[d]oxazole (CAS 1804411-94-6)
- 3-(Chloromethyl)-5-(2-furyl)isoxazole (CAS 848658-70-8)
- 4-(Chloromethyl)-2-(furan-2-yl)oxazole (CAS 202594-83-0)
- 6-(Chloromethyl)-2,3-dihydro-1,3-benzoxazol-2-one (CAS 207552-71-4)
- 6-(Chloromethyl)benzo[d]isoxazol-3(2H)-one (CAS 947408-97-1)
Recommended Standards
- 8-Chloro-1H-benzo[d][1,3]oxazin-2(4H)-one (CAS 1785201-50-4)
- (2-Chlorobenzo[d]oxazol-5-yl)methanol (CAS 1781538-68-8)
- 4-Chloro-2-methoxybenzo[d]oxazole (CAS 1806393-34-9)
- 5-Chloro-1H-benzo[d][1,3]oxazin-2(4H)-one (CAS 1780907-91-6)
- 2-(Methoxymethyl)cyclobutan-1-amine (CAS 1531895-20-1)
- 4-(2-Ethylbutanoyl)-N-[3-(1H-imidazol-1-yl)propyl]-1H-pyrrole-2-carboxamide (CAS 439112-10-4)
- 3-(Difluoromethylene)cyclobutan-1-amine (CAS 2688115-05-9)
- 5-Bromo-3-chloro-N-methoxy-N-methylpicolinamide (CAS 1383001-27-1)
- semaglutide (CAS 782487-28-9)
- 2-(4-Hydroxyphenyl)quinoline-4-carbohydrazide (CAS 351329-42-5)
- 5-(t-Butoxy)carbonyl)furan-2-boronic acid (CAS 2377608-03-0)
- N-(4-iodophenyl)-4-methoxybenzamide (CAS 304668-39-1)
- N-(4-Oxo-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-2-yl)-2-(6-oxopyridazin-1(6H)-yl)acetamide (CAS 1797698-63-5)
- 107444-51-9 0JS9125PIZ Glucagon-like peptide 1 (7-36) Glucagon-related peptide 1 (Rana catesbeiana), 3-L-glutamic acid-10-L-valine-16-glycine-17-L-glutamine-23-L-isoleucine-24-L-alanine-27-L-valine-30-L-argininamide-31-de-L-proline-32-de-L-lysine- Glp-I (7-36) Proglucagon (78-107) Human glucagon-like peptide-1-(7-36) amide Human GLP-1-(7-36)-amide Glucagon-like peptide-I(7-36) amide Rat GLP-I(7-36)amide Insulinotropin (human) MKC 253 UNII-0JS9125PIZ (CAS 107444-51-9)
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