2-(Difluoromethoxy)-1-fluoro-3-(trifluoromethyl)benzene CAS 1803848-15-8
| CAS No. | 1803848-15-8 |
| Molecular Formula | C8H4F6O |
| Molecular Weight | 230.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Difluoromethoxy)-1-fluoro-3-(trifluoromethyl)benzene (CAS 1803848-15-8), molecular formula C8H4F6O and molecular weight 230.11 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Difluoromethoxy)-1-fluoro-3-(trifluoromethyl)benzene (C8H4F6O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-(Difluoromethoxy)-1-fluoro-3-(trifluoromethyl)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4F6O |
| Molecular Weight | 230.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 4-(Difluoromethoxy)-1-fluoro-2-(trifluoromethyl)benzene (CAS 1417566-45-0)
- 1-(Difluoromethoxy)-3-fluoro-5-(trifluoromethyl)benzene (CAS 1417567-62-4)
- 1-(Difluoromethoxy)-2-fluoro-3-(trifluoromethyl)benzene (CAS 1417569-57-3)
- 4-Difluoromethoxy-3-fluorobenzotrifluoride (CAS 1803778-22-4)
- 2-Difluoromethoxy-6-fluorobenzotrifluoride (CAS 1803807-35-3)
- 2-Difluoromethoxy-5-fluorobenzotrifluoride (CAS 1803822-86-7)
- 2-Difluoromethoxy-4-fluorobenzotrifluoride (CAS 1806275-11-5)
- 4-Difluoromethoxy-2-fluorobenzotrifluoride (CAS 1807040-61-4)
Recommended Standards
- 3-(Difluoromethyl)-4-fluoro-6-(trifluoromethyl)pyridin-2-amine (CAS 1804489-12-0)
- 4-(Difluoromethyl)-3-fluoro-5-(trifluoromethyl)pyridin-2-amine (CAS 1804489-24-4)
- 2,5-Bis(trifluoromethyl)pyridin-3-amine (CAS 1803804-90-1)
- 5-(Difluoromethyl)-3-fluoro-6-(trifluoromethyl)pyridin-2-amine (CAS 1804489-31-3)
- Z-Asp-Met-OH (CAS 209548-49-2)
- Mitotan Impurity 1 (CAS 13312-58-8)
- Benzo[g]isatin (CAS 5353-96-8)
- 5-Methyl-1-(4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)-1H-pyrazole-4-carboxylic acid (CAS 2093422-14-9)
- 3,5-Dichlorobenzonitrile (CAS 6575-00-4)
- 1-(tert-Butoxycarbonyl)-3,3-difluoro-4-methylpiperidine-4-carboxylic acid (CAS 1334414-61-7)
- 3-ethyl-1-[2-(1H-pyrazol-1-yl)ethyl]piperazine (CAS 1334146-93-8)
- 4,8-Dimethyl-2-phosphabicyclo[3.3.1]nonane, min. 90%, CYTOP? 170 (CAS 328952-85-8)
- 2-Ethynyl-5-fluorobenzoic acid (CAS 1850860-05-7)
- Tirzepatide Impurity 47 (CAS CATO-C4X-324047)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com