Methyl 5-hydroxy-6-(trifluoromethyl)picolinate CAS 1804445-91-7
| CAS No. | 1804445-91-7 |
| Molecular Formula | C8H6F3NO3 |
| Molecular Weight | 221.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 5-hydroxy-6-(trifluoromethyl)picolinate.
Methyl 5-hydroxy-6-(trifluoromethyl)picolinate (CAS 1804445-91-7) is a high-purity analytical reference standard with the molecular formula C8H6F3NO3 and a molecular weight of 221.13 g/mol.
The molecular framework of Methyl 5-hydroxy-6-(trifluoromethyl)picolinate (C8H6F3NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Methyl 5-hydroxy-6-(trifluoromethyl)picolinate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6F3NO3 |
| Molecular Weight | 221.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- Methyl 6-hydroxy-5-(trifluoromethyl)picolinate (CAS 1006364-88-0)
- Methyl 4-hydroxy-6-(trifluoromethyl)picolinate (CAS 1060810-76-5)
- Methyl 2-hydroxy-6-(trifluoromethyl)isonicotinate (CAS 1060810-77-6)
- Methyl 6-hydroxy-2-(trifluoromethyl)nicotinate (CAS 1060810-81-2)
- Methyl 5-hydroxy-3-(trifluoromethyl)picolinate (CAS 1211583-10-6)
- 6-Hydroxy-2-(trifluoromethyl)pyridine-3-acetic acid (CAS 1227514-38-6)
- 2-Hydroxy-4-(trifluoromethyl)pyridine-3-acetic acid (CAS 1227514-87-5)
- 2-Hydroxy-6-(trifluoromethyl)pyridine-3-acetic acid (CAS 1227562-17-5)
Recommended Standards
- 2-(Difluoromethoxy)-3-fluoro-1-methyl-4-nitrobenzene (CAS 1803838-55-2)
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- 5-Difluoromethyl-2-(trifluoromethyl)benzonitrile (CAS 1803826-03-0)
- 2-Difluoromethyl-6-(trifluoromethyl)benzonitrile (CAS 1804515-80-7)
- 4-Chloro-2-methylphenyl 3-pyrrolidinylmethyl-ether hydrochloride (CAS 1220029-87-7)
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