2-(Chloromethyl)-3-(difluoromethyl)-5-(trifluoromethoxy)pyridine-6-acetic acid CAS 1804658-32-9
| CAS No. | 1804658-32-9 |
| Molecular Formula | C10H7ClF5NO3 |
| Molecular Weight | 319.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(Chloromethyl)-3-(difluoromethyl)-5-(trifluoromethoxy)pyridine-6-acetic acid.
CATO supplies 2-(Chloromethyl)-3-(difluoromethyl)-5-(trifluoromethoxy)pyridine-6-acetic acid (CAS 1804658-32-9), a certified reference material (molecular formula C10H7ClF5NO3, MW 319.61 g/mol) for analytical method development and quality control.
The molecular framework of 2-(Chloromethyl)-3-(difluoromethyl)-5-(trifluoromethoxy)pyridine-6-acetic acid (C10H7ClF5NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7ClF5NO3 |
| Molecular Weight | 319.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
- 2-(Chloromethyl)-3-(difluoromethyl)-5-(trifluoromethoxy)pyridine-4-acetic acid (CAS 1805155-80-9)
- 2-(Chloromethyl)-4-(difluoromethyl)-3-(trifluoromethoxy)pyridine-5-acetic acid (CAS 1805155-88-7)
- 2-(4-(Chloromethyl)-6-(difluoromethyl)-5-(trifluoromethoxy)pyridin-2-yl)acetic acid (CAS 1805156-34-6)
- 2-(Chloromethyl)-5-(difluoromethyl)-3-(trifluoromethoxy)pyridine-6-acetic acid (CAS 1805948-56-4)
- 2-(Chloromethyl)-6-(difluoromethyl)-5-(trifluoromethoxy)pyridine-3-acetic acid (CAS 1806769-76-5)
- 4-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]-N-(2,2,2-trifluoroethyl)benzamide (CAS 1119449-64-7)
- 4-(chloromethyl)-2-(4-iodophenyl)-1,3-oxazole (CAS 1179743-32-8)
- 2-(Chloromethyl)-5-(difluoromethyl)-3-hydroxy-4-iodopyridine (CAS 1804857-61-1)
Recommended Standards
- 4-Bromo-N-((5-chlorothiophen-2-yl)methyl)-1h-pyrrole-2-carboxamide (CAS 1197493-15-4)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4,4,4-trifluorobutane-1,3-dione (CAS 207994-03-4)
- 5-Chloro-N-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-2-amine (CAS 1644664-02-7)
- 3,5-dichloro-4-(2-methoxyethoxy)benzene-1-sulfonyl chloride (CAS 1178105-28-6)
- (5-Methyl-2-propan-2-yloxyphenyl)methanol (CAS 1343277-94-0)
- N-Acetyl-DL-histidine,Hydrate (CAS 10101-30-1)
- cis-4-Amino-tetrahydrofuran-3-ol (CAS 535936-61-9)
- 2,5,6-Trimethoxypyridin-3-ol (CAS 1383788-45-1)
- 2-[(1-Piperidyl)methyl]aniline (CAS 19577-83-4)
- (2S,3S,4S,5R,6S)-6-(5-Chloro-2-(2,4-dichlorophenoxy)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid (CAS 63156-12-7)
- 2,2'-(Cyclopropane-1,1-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 2222867-16-3)
- 1-(6-Aminobenzo[d]oxazol-2-yl)ethanone (CAS 1159534-45-8)
- (4-Bromo-2,5-difluorophenyl)methanamine hydrochloride (CAS 2059988-69-9)
- C-Peptide 2 (rat) (CAS 41594-08-5)
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