4-Chloro-3-(difluoromethyl)-5-(hydroxymethyl)picolinonitrile CAS 1804666-57-6
| CAS No. | 1804666-57-6 |
| Molecular Formula | C8H5ClF2N2O |
| Molecular Weight | 218.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-3-(difluoromethyl)-5-(hydroxymethyl)picolinonitrile (CAS 1804666-57-6), molecular formula C8H5ClF2N2O and molecular weight 218.59 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C8H5ClF2N2O, 4-Chloro-3-(difluoromethyl)-5-(hydroxymethyl)picolinonitrile contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 218.59 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2N2O |
| Molecular Weight | 218.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- Methyl 2-((5-chloro-6-oxo-1,6-dihydropyridazin-4-yl)oxy)acetate (CAS 1346697-65-1)
- 3-(5-Chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid (CAS 1447966-21-3)
- 2-Chloro-6-(difluoromethyl)-9-methyl-9H-purine (CAS 1706442-33-2)
- 6-Chloro-2-(difluoromethyl)-7-methyl-7H-purine (CAS 1707567-00-7)
- 6-Chloro-8-(difluoromethyl)-9-methyl-9H-purine (CAS 1708251-13-1)
- 2-Chloro-6-(difluoromethoxy)-1H-benzimidazole (CAS 1804054-68-9)
- 4-Chloro-6-(difluoromethyl)-3-(hydroxymethyl)picolinonitrile (CAS 1804487-97-5)
- 4-Chloro-6-(difluoromethyl)-5-(hydroxymethyl)nicotinonitrile (CAS 1804488-02-5)
Recommended Standards
- 6-Chloro-5-(difluoromethyl)-4-(hydroxymethyl)nicotinonitrile (CAS 1804666-23-6)
- 2-(2-Chloro-5-(difluoromethyl)-4-hydroxypyridin-3-yl)acetonitrile (CAS 1804670-67-4)
- 2-(Chloromethyl)-4-cyano-3-(difluoromethyl)-5-hydroxypyridine (CAS 1804495-16-6)
- 2-(2-Chloro-5-(difluoromethyl)-6-hydroxypyridin-3-yl)acetonitrile (CAS 1804670-76-5)
- tert-Butyl (2-bromo-4,6-dichlorophenyl)carbamate (CAS 384793-25-3)
- Ethyl (5-(furan-2-carbonyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbamate (CAS 1351607-06-1)
- 6-Fluoro-4-methylnicotinonitrile (CAS 1201192-60-0)
- tert-Butyl azetidin-3-yl(ethyl)carbamate hydrochloride (CAS 2044704-65-4)
- 1-[2-(2-Hydroxyethoxy)ethyl]-4-(2-iodobenzoyl)-piperazine (CAS 848814-26-6)
- 3-((6-Aminohexyl)amino)benzo[d]isothiazole 1,1-dioxide (CAS 309920-43-2)
- tert-butyl 3-(aminomethyl)-3-methoxyazetidine-1-carboxylate (CAS 1392804-77-1)
- 4-Ethoxycyclohexane-1-carbaldehyde (CAS 578717-93-8)
- 306936-78-7 4-(2-Methylbutyl)-5-sulfanylidene-1,2,4-triazolidin-3-one DTXSID40371443 (CAS 306936-78-7)
- Semaglutide impurity 86 (CAS CATO-C4X-222686)
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