4-Chloro-3-(difluoromethyl)-5-fluoro-2-iodopyridine CAS 1804671-52-0
| CAS No. | 1804671-52-0 |
| Molecular Formula | C6H2ClF3IN |
| Molecular Weight | 307.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-3-(difluoromethyl)-5-fluoro-2-iodopyridine.
4-Chloro-3-(difluoromethyl)-5-fluoro-2-iodopyridine (CAS 1804671-52-0) is a high-purity analytical reference standard with the molecular formula C6H2ClF3IN and a molecular weight of 307.44 g/mol.
Structurally, 4-Chloro-3-(difluoromethyl)-5-fluoro-2-iodopyridine (C6H2ClF3IN) contains a nitrile group, fluorine/chlorine/iodine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 307.44 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H2ClF3IN |
| Molecular Weight | 307.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl/I-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 4-Chloro-5-iodo-2-(trifluoromethyl)pyridine (CAS 1027818-88-7)
- 2-Chloro-3-iodo-4-(trifluoromethyl)pyridine (CAS 1186405-09-3)
- 3-Chloro-2-iodo-4-(trifluoromethyl)pyridine (CAS 1227514-97-7)
- 4-Chloro-2-iodo-3-(trifluoromethyl)pyridine (CAS 1227515-24-3)
- 3-Chloro-6-iodo-2-(trifluoromethyl)pyridine (CAS 1227515-26-5)
- 4-Chloro-2-iodo-5-(trifluoromethyl)pyridine (CAS 1227578-17-7)
- 4-Chloro-2-iodo-6-(trifluoromethyl)pyridine (CAS 1227578-22-4)
- 2-Chloro-4-iodo-3-(trifluoromethyl)pyridine (CAS 1227603-55-5)
Recommended Standards
- 2-Chloro-6-(difluoromethyl)-4-fluoro-3-iodopyridine (CAS 1804466-56-5)
- 2-Chloro-5-(difluoromethyl)-3-fluoro-4-iodopyridine (CAS 1804854-52-1)
- 3-Chloro-2-iodo-5-(trifluoromethyl)pyridine 3-chloro-2-iodo-5-trifluoromethylpyridine 134161-12-9 (CAS 134161-12-9)
- 2-Chloro-4-(difluoromethyl)-3-fluoro-5-iodopyridine (CAS 1805056-95-4)
- 4-(Naphthalen-2-ylamino)-4-oxobutanoic acid (CAS 37600-46-7)
- 2-Chloro-4,4,4-trifluoro-1-(4-fluorophenyl)butane-1,3-dione (CAS 886494-03-7)
- 3-Methylquinoline-2-carboxylic acid (CAS 92513-28-5)
- 7-Benzoyl-11-(2-chlorophenyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one (CAS 297160-46-4)
- 6-Bromo-2,2-dimethyl-2,3-dihydro-1H-inden-1-ol (CAS 1188042-00-3)
- (S)-Methyl 2-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)benzoate (CAS 1515857-06-3)
- 3-amino-1-ethyl-5-methyl-2,3-dihydro-1H-indol-2-one hydrochloride (CAS 1443979-70-1)
- 2-Propyl-1,2,3,4-tetrahydronaphthalen-1-one (CAS 50417-78-2)
- (3R,4R)-Pyrrolidine-3,4-diol hydrochloride (CAS 1104000-68-1)
- Insulin Degludec Impurity 19 (CAS CATO-C4X-215719)
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