2-Chloro-4-(difluoromethyl)-5-fluoro-3-methylpyridine CAS 1804672-52-3

Purity 97%+In StockPharmaceutical Standards
CAS No.1804672-52-3
Molecular FormulaC7H5ClF3N
Molecular Weight195.57 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-Chloro-4-(difluoromethyl)-5-fluoro-3-methylpyridine CAS 1804672-52-3 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-4-(difluoromethyl)-5-fluoro-3-methylpyridine.

2-Chloro-4-(difluoromethyl)-5-fluoro-3-methylpyridine (CAS 1804672-52-3) is a high-purity analytical reference standard with the molecular formula C7H5ClF3N and a molecular weight of 195.57 g/mol.

Structurally, 2-Chloro-4-(difluoromethyl)-5-fluoro-3-methylpyridine (C7H5ClF3N) contains a nitrile group, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 195.57 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC7H5ClF3N
Molecular Weight195.57 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1995
Halogen ContentF/Cl-containing
Nitrogen Atoms1

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