Solifenacin EP impurity F HCl CAS 180468-40-0
| CAS No. | 180468-40-0 |
| Molecular Formula | C23H26N2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Solifenacin EP impurity F HCl (CAS 180468-40-0, C23H26N2O2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Solifenacin EP impurity F HCl (C23H26N2O2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 398.93 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C23H26N2O2 HCl |
| Molecular Weight | 398.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Solifenacin Standards
- Solifenacin Impurity 19 (CAS 1029430-94-1)
- Solifenacin Impurity 8 (HCl) (CAS 1159826-34-2)
- Solifenacin EP Impurity A (CAS 118864-75-8)
- Solifenacin Impurity 31 (CAS 1193-65-3)
- Solifenacin Impurity 28 (CAS 120577-33-5)
- Solifenacin Impurity 34 (CAS 1243274-81-8)
- Solifenacin Impurity 16 (CAS 134021-15-1)
- Solifenacin EP Impurity B (CAS 1353274-25-5)
Recommended Standards
- Levofloxacin impurity 02 (CAS 3403-82-5)
- Peficitinib Impurity 10 (CAS 944118-24-5)
- Lurbinectedin Impurity 35 (CAS CATO-C4X-311435)
- Ethyl 1-(difluoromethyl)-5-methyl-1H-pyrazole-3-carboxylate (CAS 1998216-36-6)
- (8E,10E)-Octadeca-8,10-dienoic acid (CAS 115863-92-8)
- Methyl 3-amino-4-ethylhexanoate (CAS 1250148-09-4)
- 2-Chloro-2-Fluoro-1-Methylcyclopropanecarbonyl Chloride (CAS 128230-83-1)
- 4-Amino-N-(2-ethoxyphenyl)benzamide (CAS 180466-21-1)
- 3-(tert-Butoxy)-2-iodophenol (CAS 1243391-15-2)
- Semaglutide impurity 277 (CAS CATO-C4X-2226277)
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