4-(Aminomethyl)-6-(difluoromethyl)nicotinoyl chloride CAS 1804697-05-9

Purity 97%+In StockPharmaceutical Standards
CAS No.1804697-05-9
Molecular FormulaC8H7ClF2N2O
Molecular Weight220.60 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

4-(Aminomethyl)-6-(difluoromethyl)nicotinoyl chloride CAS 1804697-05-9 chemical structure

Description

4-(Aminomethyl)-6-(difluoromethyl)nicotinoyl chloride (CAS 1804697-05-9) is a high-purity analytical reference standard with the molecular formula C8H7ClF2N2O and a molecular weight of 220.60 g/mol.

The molecular framework of 4-(Aminomethyl)-6-(difluoromethyl)nicotinoyl chloride (C8H7ClF2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 4-(Aminomethyl)-6-(difluoromethyl)nicotinoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC8H7ClF2N2O
Molecular Weight220.60 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1995
Halogen ContentF/Cl-containing
Nitrogen Atoms2

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