4,6-Diamino-5-(difluoromethyl)nicotinaldehyde CAS 1804710-99-3
| CAS No. | 1804710-99-3 |
| Molecular Formula | C7H7F2N3O |
| Molecular Weight | 187.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4,6-Diamino-5-(difluoromethyl)nicotinaldehyde.
CATO supplies 4,6-Diamino-5-(difluoromethyl)nicotinaldehyde (CAS 1804710-99-3), a certified reference material (molecular formula C7H7F2N3O, MW 187.15 g/mol) for analytical method development and quality control.
The molecular framework of 4,6-Diamino-5-(difluoromethyl)nicotinaldehyde (C7H7F2N3O) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7F2N3O |
| Molecular Weight | 187.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Diamino Standards
- 2,3-Diamino-4-(difluoromethyl)pyridine-6-carboxaldehyde (CAS 1804710-83-5)
- 4,5-Diamino-3-(difluoromethyl)picolinaldehyde (CAS 1804711-03-2)
- 2,4-Diamino-5-(difluoromethyl)nicotinaldehyde (CAS 1805001-12-0)
- 5,6-Diamino-2-(difluoromethyl)nicotinaldehyde (CAS 1805236-03-6)
- 2,6-Diamino-5-(difluoromethyl)nicotinaldehyde (CAS 1805236-26-3)
- 4,5-Diamino-2-(difluoromethyl)nicotinaldehyde (CAS 1805236-38-7)
- 2,5-Diamino-3-(difluoromethyl)isonicotinaldehyde (CAS 1805315-75-6)
- 4,6-Diamino-5-nitropyrimidine-2(1H)-thione (CAS 98019-84-2)
Recommended Standards
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- N-(2,6-difluorophenyl)hydrazinecarboxamide (CAS 171277-87-5)
- 3-(2-Methoxyethoxy)isoxazole-5-carboxylic acid (CAS 1708208-64-3)
- 2-[1-(2,5-Dichloro-3-thienyl)ethylidene]-1-hydrazinecarbothioamide (CAS 866149-92-0)
- Ethyl 2-(phenylthio)quinoline-4-carboxylate (CAS 6949-89-9)
- (S)-5-(2-Amino-2-carboxyethyl)-2-hydroxybenzoic acid (CAS 4303-95-1)
- rel-tert-Butyl (3R,4S)-3-ethyl-4-hydroxypyrrolidine-1-carboxylate (CAS 1228880-43-0)
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- Ethyl1-amino-1H-pyrrole-2-carboxylatehydrochloride (CAS 1159825-10-1)
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