4-(Difluoromethyl)-2-fluoro-6-methoxypyridine CAS 1804754-74-2
| CAS No. | 1804754-74-2 |
| Molecular Formula | C7H6F3NO |
| Molecular Weight | 177.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-(Difluoromethyl)-2-fluoro-6-methoxypyridine (CAS 1804754-74-2) is a high-purity analytical reference standard with the molecular formula C7H6F3NO and a molecular weight of 177.12 g/mol.
The molecular framework of 4-(Difluoromethyl)-2-fluoro-6-methoxypyridine (C7H6F3NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 4-(Difluoromethyl)-2-fluoro-6-methoxypyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6F3NO |
| Molecular Weight | 177.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- (4-(Difluoromethyl)-6-fluoropyridin-2-yl)methanol (CAS 1803665-93-1)
- 4-(Difluoromethyl)-3-(fluoromethyl)pyridin-2-ol (CAS 1805036-09-2)
- 4-(Difluoromethyl)-3-fluoro-2-methoxypyridine (CAS 1805117-79-6)
- 3-(Difluoromethyl)-2-fluoro-6-methoxypyridine (CAS 1805304-64-6)
- 3-(Difluoromethyl)-5-fluoro-2-methoxypyridine (CAS 1805304-69-1)
- 4-(Difluoromethyl)-2-fluoro-5-methoxypyridine (CAS 1805304-71-5)
- (6-(Difluoromethyl)-3-fluoropyridin-2-yl)methanol (CAS 1805312-17-7)
- 4-(Difluoromethyl)-5-(fluoromethyl)pyridin-3-ol (CAS 1805320-17-5)
Recommended Standards
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- 2-Methoxy-5-(trifluoromethyl)pyridine (CAS 175277-45-9)
- 2-Methyl-6-trifluoromethyl-pyridin-4-ol (CAS 1622843-95-1)
- 2,5,8,11-tetramethyldodec-6-yne-5,8-diol (CAS 68227-33-8)
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- 4-Chloro-6-propylquinoline (CAS 1156602-03-7)
- N-(2,4-dichlorophenyl)-N-(2-oxo-2-(piperidin-1-yl)ethyl)methanesulfonamide (CAS 343374-06-1)
- Isoquinoline-4-sulfonyl chloride (CAS 347146-79-6)
- Levonorgestrel EP Impurity P (CAS 100021-05-4)
- 2,4-Difluoro-5-propoxyphenol (CAS 1881295-35-7)
- (Pyr1)-Opiorphin (CAS 1189350-60-4)
- N-Benzoyl-N-(2,3,4,5,6-pentafluorophenyl)thiourea (CAS 860609-73-0)
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