5-(Difluoromethyl)-4-hydroxypyridine-2-carboxamide CAS 1805005-01-9
| CAS No. | 1805005-01-9 |
| Molecular Formula | C7H6F2N2O2 |
| Molecular Weight | 188.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(Difluoromethyl)-4-hydroxypyridine-2-carboxamide.
5-(Difluoromethyl)-4-hydroxypyridine-2-carboxamide (CAS 1805005-01-9), molecular formula C7H6F2N2O2 and molecular weight 188.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-(Difluoromethyl)-4-hydroxypyridine-2-carboxamide (C7H6F2N2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6F2N2O2 |
| Molecular Weight | 188.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 6-(Difluoromethyl)-4-oxo-1,4-dihydropyridine-2-carboxamide (CAS 1229624-71-8)
- 2-(Difluoromethyl)-3-nitroaniline (CAS 1261568-79-9)
- 2-(Difluoromethyl)-5-nitroaniline (CAS 1261605-86-0)
- 2-(Difluoromethyl)-4-nitroaniline (CAS 1261617-68-8)
- 4-(Difluoromethyl)-3-nitroaniline (CAS 1261646-06-3)
- 2-(Difluoromethyl)-6-nitroaniline (CAS 1261825-91-5)
- 4-(Difluoromethyl)-2-methylpyrimidine-5-carboxylic acid (CAS 1339801-32-9)
- Methyl 4-(Difluoromethyl)pyrimidine-2-carboxylate (CAS 1355729-56-4)
Recommended Standards
- 2-(Difluoromethyl)-6-hydroxyisonicotinamide (CAS 1805004-98-1)
- 4-(Difluoromethyl)-6-hydroxypyridine-3-carboxamide (CAS 1805005-16-6)
- 2-(Difluoromethyl)-5-hydroxypyridine-3-carboxamide (CAS 1805004-92-5)
- 5-(Difluoromethyl)-2-hydroxypyridine-4-carboxamide (CAS 1805005-25-7)
- tert-Butyl (2S,4R)-4-amino-2-methylpiperidine-1-carboxylate hydrochloride (CAS 2305079-06-3)
- 1-[(4-Isothiocyanatophenyl)sulfonyl]indoline (CAS 895935-43-0)
- 2-(2-(Nicotinamido)thiazol-4-yl)acetic acid hydrate (CAS 1421457-35-3)
- 1-(Prop-2-yn-1-yl)-1,2-dihydropyridin-2-one (CAS 36281-70-6)
- 2-Methyl-3-(4-methyl-1h-pyrazol-1-yl)-2-(propylamino)propanamide (CAS 1249787-88-9)
- 109741-38-0 2H-1-Benzopyran-2-one,8-[(1E)-3-hydroxy-3-methyl-1-buten-1-yl]-7-methoxy- (CAS 109741-38-0)
- 4-Bromo-N,N,1-tris(4-methoxybenzyl)-1H-pyrazol-3-amine (CAS 930286-87-6)
- N-(3-chloro-4-methoxyphenyl)acetamide (CAS 7073-42-9)
- 4-Amino-5,5-dimethyl-1,2,4-triazolidine-3-thione (CAS 130413-23-9)
- Semaglutide impurity 197 (CAS CATO-C4X-2226197)
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