4-(Difluoromethyl)-5-methoxy-3-(trifluoromethoxy)picolinic acid CAS 1805099-99-3
| CAS No. | 1805099-99-3 |
| Molecular Formula | C9H6F5NO4 |
| Molecular Weight | 287.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 4-(Difluoromethyl)-5-methoxy-3-(trifluoromethoxy)picolinic acid (CAS 1805099-99-3), a certified reference material (molecular formula C9H6F5NO4, MW 287.14 g/mol) for analytical method development and quality control.
The molecular framework of 4-(Difluoromethyl)-5-methoxy-3-(trifluoromethoxy)picolinic acid (C9H6F5NO4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H6F5NO4 |
| Molecular Weight | 287.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 2-(4-(Difluoromethyl)-5-hydroxy-3-(trifluoromethoxy)pyridin-2-yl)acetic acid (CAS 1803963-01-0)
- 2-(Difluoromethyl)-3-hydroxy-5-(trifluoromethoxy)pyridine-6-acetic acid (CAS 1804359-32-7)
- 4-(Difluoromethyl)-6-methoxy-5-(trifluoromethoxy)nicotinic acid (CAS 1804479-67-1)
- 2-(Difluoromethyl)-3-hydroxy-6-(trifluoromethoxy)pyridine-5-acetic acid (CAS 1804798-01-3)
- 2-(Difluoromethyl)-4-hydroxy-3-(trifluoromethoxy)pyridine-6-acetic acid (CAS 1804837-46-4)
- 2-(4-(Difluoromethyl)-6-hydroxy-5-(trifluoromethoxy)pyridin-2-yl)acetic acid (CAS 1804837-61-3)
- 4-(Difluoromethyl)-3-methoxy-6-(trifluoromethoxy)picolinic acid (CAS 1804953-96-5)
- 2-(Difluoromethyl)-5-methoxy-3-(trifluoromethoxy)pyridine-6-carboxylic acid (CAS 1805099-78-8)
Recommended Standards
- 2-(Difluoromethyl)-5-methoxy-6-(trifluoromethoxy)pyridine-3-carboxylic acid (CAS 1806018-62-1)
- 2-(Difluoromethyl)-6-methoxy-3-(trifluoromethoxy)pyridine-5-carboxylic acid (CAS 1806018-69-8)
- 2-(Difluoromethyl)-4-hydroxy-6-(trifluoromethoxy)pyridine-3-acetic acid (CAS 1806047-35-7)
- 2-(Difluoromethyl)-6-hydroxy-4-(trifluoromethoxy)pyridine-3-acetic acid (CAS 1806047-98-2)
- 4-((Cyclopropylmethyl)amino)cyclohexan-1-ol (CAS 1156282-89-1)
- (2-Fluoro-6-(furan-3-yl)pyridin-3-yl)boronic acid (CAS 2225154-62-9)
- 1H-Pyrrole-3-carboxylic acid hydrate (CAS 1195901-40-6)
- 2-Amino-4-methylpentanoic acid isopropylamide (CAS 1161070-80-9)
- (5R,9R,10R,13S,14S,17S)-4,4,10,13,14-Pentamethyl-17-((2S,4R,5S)-4,5,6-trihydroxy-6-methylheptan-2-yl)-4,5,6,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta (CAS 100198-09-2)
- 1-Benzyl-2,4,5-tribromo-1H-imidazole (CAS 31250-80-3)
- N-(tert-Butyl)-6-phenylimidazo[1,2-a]pyridin-3-amine (CAS 1632065-68-9)
- N-(3-bromobenzyl)tetrahydro-2H-thiopyran-4-amine hydrochloride (CAS 1803566-42-8)
- 2-(2R)-2-Piperidinylpyridine (CAS 1061659-74-2)
- Dendroaspis Natriuretic Peptide (CAS 255721-52-9)
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