4-Amino-5-(difluoromethyl)-2-hydroxynicotinoyl chloride CAS 1805211-84-0
| CAS No. | 1805211-84-0 |
| Molecular Formula | C7H5ClF2N2O2 |
| Molecular Weight | 222.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Amino-5-(difluoromethyl)-2-hydroxynicotinoyl chloride.
4-Amino-5-(difluoromethyl)-2-hydroxynicotinoyl chloride (CAS 1805211-84-0), molecular formula C7H5ClF2N2O2 and molecular weight 222.58 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C7H5ClF2N2O2, 4-Amino-5-(difluoromethyl)-2-hydroxynicotinoyl chloride contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 222.58 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Amino-5-(difluoromethyl)-2-hydroxynicotinoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5ClF2N2O2 |
| Molecular Weight | 222.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 4-Amino-3-chloro-6-(difluoromethyl)picolinic acid (CAS 1796589-44-0)
- 6-Amino-3-chloro-5-(difluoromethyl)picolinic acid (CAS 1803668-45-2)
- 2-Amino-6-chloro-4-(difluoromethyl)nicotinic acid (CAS 1803668-49-6)
- 4-Amino-6-chloro-3-(difluoromethyl)pyridine-2-carboxylic acid (CAS 1804451-66-8)
- 4-Amino-6-chloro-5-(difluoromethyl)picolinic acid (CAS 1805008-61-0)
- 6-Amino-4-chloro-5-(difluoromethyl)picolinic acid (CAS 1805061-78-2)
- 6-Amino-2-chloro-5-(difluoromethyl)nicotinic acid (CAS 1805061-87-3)
- 2-Amino-6-chloro-5-(difluoromethyl)nicotinic acid (CAS 1805100-86-0)
Recommended Standards
- 4-Amino-2-(difluoromethyl)-6-hydroxynicotinoyl chloride (CAS 1805211-71-5)
- 2-Chloro-4-(difluoromethyl)-5-methyl-3-nitropyridine (CAS 1805268-45-4)
- 4-Amino-6-chloro-2-(difluoromethyl)nicotinic acid (CAS 1805101-06-7)
- 2-Chloro-5-(difluoromethyl)-3-methyl-4-nitropyridine (CAS 1805268-50-1)
- N-(Benzo[d]thiazol-2-yl)-3-(p-tolylthio)propanamide (CAS 895461-02-6)
- N-(4-Nitrophenyl)pyridin-2-amine (CAS 24068-29-9)
- (S)-2-Bromo-4-methylpentanoic acid (CAS 28659-87-2)
- 5-Amino-4-bromo-2,2-dimethylbenzo[b]thiophen-3(2H)-one 1,1-dioxide (CAS 2665671-76-9)
- N-((1-Propyl-1H-pyrazol-3-yl)methyl)pentan-1-amine hydrochloride (CAS 1856036-53-7)
- 2-Amino-1-(2,3-dimethoxyphenyl)ethan-1-ol (CAS 17055-25-3)
- Isoquinolin-3-ylmethanamine dihydrochloride (CAS 157405-77-1)
- 5,6,7,8-Tetrahydronaphthalene-2-thiol (CAS 24634-91-1)
- 1-Ethoxypropene (CAS 928-55-2)
- Semaglutide Impurity 4 (CAS CATO-C4X-22264)
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