2-(Difluoromethyl)-6-hydroxy-5-nitropyridine-3-acetic acid CAS 1805253-76-2
| CAS No. | 1805253-76-2 |
| Molecular Formula | C8H6F2N2O5 |
| Molecular Weight | 248.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Difluoromethyl)-6-hydroxy-5-nitropyridine-3-acetic acid (C8H6F2N2O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-(Difluoromethyl)-6-hydroxy-5-nitropyridine-3-acetic acid (CAS 1805253-76-2), molecular formula C8H6F2N2O5 and molecular weight 248.14 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6F2N2O5 |
| Molecular Weight | 248.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 2-(4-(Difluoromethyl)-6-hydroxy-5-nitropyridin-2-yl)acetic acid (CAS 1805069-20-8)
- 2-(Difluoromethyl)-6-hydroxy-4-nitropyridine-3-acetic acid (CAS 1805092-83-4)
- 2-(Difluoromethyl)-5-hydroxy-4-nitropyridine-3-acetic acid (CAS 1805093-82-6)
- 2-(4-(Difluoromethyl)-3-hydroxy-5-nitropyridin-2-yl)acetic acid (CAS 1805094-09-0)
- 2-(Difluoromethyl)-5-methoxy-3-nitropyridine-6-carboxylic acid (CAS 1805262-67-2)
- 4-(Difluoromethyl)-3-methoxy-5-nitropicolinic acid (CAS 1805263-05-1)
- 2-(Difluoromethyl)-3-methoxy-4-nitropyridine-5-carboxylic acid (CAS 1805466-18-5)
- 2-(4-(Difluoromethyl)-6-hydroxy-5-nitropyridin-3-yl)acetic acid (CAS 1805539-76-7)
Recommended Standards
- 2-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)ethanethioamide (CAS 175202-68-3)
- 2-(Difluoromethyl)-4-hydroxy-5-nitropyridine-3-acetic acid (CAS 1805541-55-2)
- ((3-Bromophenyl)imino)dimethyl-lambda6-sulfanone (CAS 1628604-87-4)
- 2-(Difluoromethyl)-4-methoxy-3-nitropyridine-5-carboxylic acid (CAS 1805607-00-4)
- 5,5'-Dibromo-4,4'-dihexyl-2,2'-bithiophene (CAS 214493-03-5)
- 1-(3,4-Difluoro-5-(isopentyloxy)phenyl)ethanone (CAS 1443349-85-6)
- But-3-ene-1,2,3-tricarboxylic acid (CAS 26326-05-6)
- (2S)-2-methyltetrahydropyran-2-carboxylic acid (CAS 2306253-18-7)
- 2,6-Dichloro-3-phenylquinazolin-4(3H)-one (CAS 31797-22-5)
- 4-Bromo-3-cyano-2-(difluoromethyl)pyridine-5-methanol (CAS 1806998-35-5)
- 2-Amino-3-(5-(tert-butyl)-3-oxo-2,3-dihydroisoxazol-4-yl)propanoic acid (CAS 140158-50-5)
- Tert-butyl 4-(4-(methoxycarbonyl)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate (CAS 937601-48-4)
- 1869954-38-0 [1-(2,2-dimethylpropyl)-1H-indol-3-yl]-2-naphthalenyl-methanone (CAS 1869954-38-0)
- Des-Tyr10-Tirzepatide (CAS CATO-CPTD788680)
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