4-(Difluoromethyl)-6-iodo-3-methylpicolinoyl chloride CAS 1805266-75-4
| CAS No. | 1805266-75-4 |
| Molecular Formula | C8H5ClF2INO |
| Molecular Weight | 331.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Difluoromethyl)-6-iodo-3-methylpicolinoyl chloride.
CATO supplies 4-(Difluoromethyl)-6-iodo-3-methylpicolinoyl chloride (CAS 1805266-75-4), a certified reference material (molecular formula C8H5ClF2INO, MW 331.49 g/mol) for analytical method development and quality control.
The molecular framework of 4-(Difluoromethyl)-6-iodo-3-methylpicolinoyl chloride (C8H5ClF2INO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2INO |
| Molecular Weight | 331.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl/I-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-3-iodo-6-methylpyridine-4-carbonyl chloride (CAS 1805421-65-1)
- 4-(Difluoromethyl)-5-iodo-6-methylpicolinoyl chloride (CAS 1805421-94-6)
- 2-(Difluoromethyl)-4-iodo-3-methylpyridine-6-carbonyl chloride (CAS 1805511-00-5)
- 4-(Difluoromethyl)-2-iodo-5-methylnicotinoyl chloride (CAS 1805516-40-8)
- 2-(Difluoromethyl)-4-iodo-3-methylpyridine-5-carbonyl chloride (CAS 1805607-70-8)
- 2-(Difluoromethyl)-4-iodo-5-methylpyridine-3-carbonyl chloride (CAS 1805607-75-3)
- 4-(Difluoromethyl)-6-iodo-5-methylnicotinoyl chloride (CAS 1805608-19-8)
- 2-(Difluoromethyl)-6-iodo-3-methylpyridine-5-carbonyl chloride (CAS 1806022-38-7)
Recommended Standards
- 2-(Chloromethyl)-5-(difluoromethyl)-6-iodopyridine-3-carboxaldehyde (CAS 1805067-09-7)
- Amorolfine Hydrochloride - Impurity G (CAS 1260498-34-7)
- ((1S,4s)-4-(hydroxymethyl)-4'-propyl-[1,1'-bi(cyclohexan)]-4-yl)methanesulfonate (CAS 1215227-72-7)
- N-Octyl-4-(2-thioxo-2,3-dihydro-1H-imidazol-1-yl)benzamide (CAS 95234-93-8)
- Methyl-1,2,3,6-tetrahydrophthalic Anhydride (mixture of isomers) (CAS 26590-20-5)
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