4-Bromo-5-(difluoromethyl)-2-methoxypyridine-3-methanol CAS 1805351-79-4
| CAS No. | 1805351-79-4 |
| Molecular Formula | C8H8BrF2NO2 |
| Molecular Weight | 268.06 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-Bromo-5-(difluoromethyl)-2-methoxypyridine-3-methanol (C8H8BrF2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4-Bromo-5-(difluoromethyl)-2-methoxypyridine-3-methanol (CAS 1805351-79-4), molecular formula C8H8BrF2NO2 and molecular weight 268.06 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 4-Bromo-5-(difluoromethyl)-2-methoxypyridine-3-methanol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H8BrF2NO2 |
| Molecular Weight | 268.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- (4-Bromo-3-(difluoromethyl)-5-methoxypyridin-2-yl)methanol (CAS 1805351-78-3)
- Methyl 2-bromo-3-cyano-5-formylbenzoate (CAS 1805407-11-7)
- 4-Bromo-2-(difluoromethyl)-5-methoxypyridine-3-methanol (CAS 1805351-76-1)
- Methyl 2-bromo-4-cyano-5-formylbenzoate (CAS 1805407-26-4)
- N-(Cyanomethyl)-5-(trifluoromethyl)pyridazine-4-carboxamide (CAS 872780-83-1)
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