4-(Aminomethyl)-2-bromo-5-(difluoromethyl)nicotinic acid CAS 1805352-50-4
| CAS No. | 1805352-50-4 |
| Molecular Formula | C8H7BrF2N2O2 |
| Molecular Weight | 281.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Aminomethyl)-2-bromo-5-(difluoromethyl)nicotinic acid.
4-(Aminomethyl)-2-bromo-5-(difluoromethyl)nicotinic acid (CAS 1805352-50-4), molecular formula C8H7BrF2N2O2 and molecular weight 281.05 g/mol, is a CATO reference standard with documented purity and traceability.
4-(Aminomethyl)-2-bromo-5-(difluoromethyl)nicotinic acid (C8H7BrF2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-(Aminomethyl)-2-bromo-5-(difluoromethyl)nicotinic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7BrF2N2O2 |
| Molecular Weight | 281.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Aminomethyl Standards
- 2-(Aminomethyl)-3-bromo-5-(difluoromethyl)pyridine-4-carboxylic acid (CAS 1804434-20-5)
- 2-(Aminomethyl)-6-bromo-3-(difluoromethyl)pyridine-5-carboxylic acid (CAS 1804487-68-0)
- 2-(Aminomethyl)-4-bromo-6-(difluoromethyl)pyridine-3-carboxylic acid (CAS 1804667-32-0)
- 2-(Aminomethyl)-5-bromo-3-(difluoromethyl)pyridine-6-carboxylic acid (CAS 1805038-27-0)
- 4-(Aminomethyl)-3-bromo-5-(difluoromethyl)picolinic acid (CAS 1805168-91-5)
- 2-(Aminomethyl)-3-bromo-6-(difluoromethyl)pyridine-4-carboxylic acid (CAS 1805254-88-9)
- 2-(Aminomethyl)-5-bromo-4-(difluoromethyl)pyridine-3-carboxylic acid (CAS 1805254-97-0)
- 4-(Aminomethyl)-6-bromo-3-(difluoromethyl)picolinic acid (CAS 1806857-13-5)
Recommended Standards
- 2-Amino-6-(bromomethyl)-4-(difluoromethyl)nicotinic acid (CAS 1805346-45-5)
- 2-(Bromomethyl)-5-(difluoromethyl)-4-methyl-3-nitropyridine (CAS 1805558-13-7)
- 2-Amino-4-(bromomethyl)-6-(difluoromethyl)nicotinic acid (CAS 1805346-39-7)
- 2-(Bromomethyl)-6-(difluoromethyl)-5-methyl-3-nitropyridine (CAS 1805558-22-8)
- (S)-4-amino-4-phenylbutan-1-ol (CAS 949096-34-8)
- 2-Azaspiro[3.3]heptane Hydrochloride (CAS 1420271-08-4)
- Norgestomet (CAS 25092-41-5)
- 3,3-Dimethylcyclohexane-1-carboxylic acid (CAS 52209-77-5)
- N,1-Dimethyl-1H-imidazol-2-amine (CAS 1083224-07-0)
- 1-(Adamantan-1-yl)-2-bromopropan-1-one (CAS 26525-24-6)
- 1-(Tert-butoxycarbonyl)-4-(3-methoxyphenyl)piperidine-4-carboxylic acid (CAS 1158750-63-0)
- 1-(2-Methylthiazole-4-carbonyl)piperidine-3-carboxylic acid (CAS 1486726-11-7)
- 1-(2'-Fluoro[1,1'-biphenyl]-2-yl)ethanone (CAS 140483-62-1)
- Peptide 431 (CAS CATO-CPTD788431)
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