6-Bromo-4-(difluoromethyl)-5-(trifluoromethyl)nicotinonitrile CAS 1805386-91-7

Purity 97%+In StockPharmaceutical Standards
CAS No.1805386-91-7
Molecular FormulaC8H2BrF5N2
Molecular Weight301.01 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

6-Bromo-4-(difluoromethyl)-5-(trifluoromethyl)nicotinonitrile CAS 1805386-91-7 chemical structure

Description

The occurrence of 6-Bromo-4-(difluoromethyl)-5-(trifluoromethyl)nicotinonitrile is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies 6-Bromo-4-(difluoromethyl)-5-(trifluoromethyl)nicotinonitrile (CAS 1805386-91-7), a certified reference material (molecular formula C8H2BrF5N2, MW 301.01 g/mol) for analytical method development and quality control.

The molecular framework of 6-Bromo-4-(difluoromethyl)-5-(trifluoromethyl)nicotinonitrile (C8H2BrF5N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.

As a certified reference material (CRM), 6-Bromo-4-(difluoromethyl)-5-(trifluoromethyl)nicotinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC8H2BrF5N2
Molecular Weight301.01 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1995
Halogen ContentF/Br-containing
Nitrogen Atoms2

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