2-Chloro-5-(difluoromethyl)-6-iodonicotinonitrile CAS 1805400-17-2
| CAS No. | 1805400-17-2 |
| Molecular Formula | C7H2ClF2IN2 |
| Molecular Weight | 314.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Chloro-5-(difluoromethyl)-6-iodonicotinonitrile (C7H2ClF2IN2) is characterized by a nitrile group, fluorine/chlorine/iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 2-Chloro-5-(difluoromethyl)-6-iodonicotinonitrile (CAS 1805400-17-2), a certified reference material (molecular formula C7H2ClF2IN2, MW 314.46 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Chloro-5-(difluoromethyl)-6-iodonicotinonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H2ClF2IN2 |
| Molecular Weight | 314.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl/I-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-3-(difluoromethyl)-6-iodopicolinonitrile (CAS 1804673-12-8)
- 2-Chloro-6-(difluoromethyl)-3-iodoisonicotinonitrile (CAS 1805049-35-7)
- 6-Chloro-4-(difluoromethyl)-5-iodonicotinonitrile (CAS 1805049-43-7)
- 6-Chloro-5-(difluoromethyl)-4-iodopicolinonitrile (CAS 1805360-56-8)
- 2-Chloro-3-(difluoromethyl)-5-iodoisonicotinonitrile (CAS 1805380-45-3)
- 6-Chloro-5-(difluoromethyl)-2-iodonicotinonitrile (CAS 1805380-58-8)
- 6-Chloro-2-(difluoromethyl)-5-iodonicotinonitrile (CAS 1805380-64-6)
- 4-Chloro-2-(difluoromethyl)-6-iodonicotinonitrile (CAS 1805381-11-6)
Recommended Standards
- 4-Chloro-6-(difluoromethyl)-5-iodopicolinonitrile (CAS 1805400-68-3)
- 4-Chloro-2-(difluoromethyl)-5-iodonicotinonitrile (CAS 1806926-40-8)
- 6-Chloro-4-(difluoromethyl)-5-iodopicolinonitrile (CAS 1807028-46-1)
- 2,3,4,9-Tetrahydro-3,9,9-trimethyl-6-pentyl-1H-xanthen-8-ol (CAS 18110-59-3)
- SD36LG60G1 22398-80-7 Indium phosphide Indium phosphide (InP) EINECS 244-959-5 Indium monophosphide HSDB 6935 CCRIS 8799 UNII-SD36LG60G1 (CAS 22398-80-7)
- 4-Bromo-2-chloro-L-phenylalanine (CAS 1213036-69-1)
- 2,6-Dichlorophenylboronic Acid (CAS 73852-17-2)
- N-(3-((3-(dimethylamino)propyl)amino)propyl)isonicotinamide (CAS 402777-69-9)
- N-(3,4,5-trimethoxyphenyl)propionamide (CAS 91645-63-5)
- Methyl 3-methoxy-5-(3-methylphenyl)benzoate (CAS 1820603-40-4)
- Methyl (R)-2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)propanoate (CAS 1363378-06-6)
- 4-Acetyl-3-methyl-1-phenyl-1H-pyrazol-5-yl acetate (CAS 64360-23-2)
- (5-(Tetrahydro-2h-pyran-4-yl)-4h-1,2,4-triazol-3-yl)methanamine (CAS 1541129-07-0)
- D-[Phe]6-Liraglutide (CAS CATO-C4X-199235)
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