4-Bromo-6-(difluoromethyl)-5-methoxypicolinoyl chloride CAS 1805426-41-8
| CAS No. | 1805426-41-8 |
| Molecular Formula | C8H5BrClF2NO2 |
| Molecular Weight | 300.48 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Bromo-6-(difluoromethyl)-5-methoxypicolinoyl chloride.
4-Bromo-6-(difluoromethyl)-5-methoxypicolinoyl chloride (CAS 1805426-41-8), molecular formula C8H5BrClF2NO2 and molecular weight 300.48 g/mol, is a CATO reference standard with documented purity and traceability.
4-Bromo-6-(difluoromethyl)-5-methoxypicolinoyl chloride (C8H5BrClF2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5BrClF2NO2 |
| Molecular Weight | 300.48 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 2-Bromo-6-(chloromethyl)-4-(difluoromethyl)nicotinic acid (CAS 1804668-55-0)
- 6-Bromo-4-(chloromethyl)-5-(difluoromethyl)nicotinic acid (CAS 1805250-45-6)
- 4-Bromo-3-chloro-2-(difluoromethyl)pyridine-6-acetic acid (CAS 1805341-30-3)
- 4-Bromo-2-chloro-3-(difluoromethyl)pyridine-6-acetic acid (CAS 1805356-36-8)
- 6-Bromo-5-(chloromethyl)-3-(difluoromethyl)picolinic acid (CAS 1805392-19-1)
- 2-(6-Bromo-4-chloro-5-(difluoromethyl)pyridin-2-yl)acetic acid (CAS 1805397-00-5)
- 2-(2-Bromo-5-chloro-4-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1805397-13-0)
- 2-(2-Bromo-6-chloro-4-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1805397-17-4)
Recommended Standards
- 2-(Bromomethyl)-5-chloro-3-(difluoromethyl)pyridine-4-carboxylic acid (CAS 1805417-94-0)
- 4-Bromo-5-(difluoromethyl)-6-methoxypicolinoyl chloride (CAS 1805426-48-5)
- 4-Bromo-3-(difluoromethyl)-6-methoxypyridine-2-carbonyl chloride (CAS 1805426-58-7)
- 2-(6-Bromo-2-chloro-5-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1805451-24-4)
- N-Fmoc-L-threonine Allyl Ester (CAS 136523-92-7)
- Methyl 4-chloro-3-methylthiophene-2-carboxylate (CAS 683787-70-4)
- n-(4-Bromo-3-methylphenyl)-2-chloropropanamide (CAS 1016746-86-3)
- (4-(Oxazol-2-yl)phenyl)methanamine (CAS 885466-67-1)
- 4-Formyl-2-methoxyphenyl 2,4-dichlorobenzoate (CAS 321968-49-4)
- Methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate hydrochloride (CAS 1215833-62-7)
- (1H-indol-2-yl)(4-(pyrimidin-2-yl)piperazin-1-yl)methanone (CAS 1027418-37-6)
- alpha-Methylfentanyl hydrochloride (CAS 1443-44-3)
- 2-(2-Ethoxy-4-formyl-6-iodophenoxy)-N-(2-methoxyphenyl)acetamide (CAS 832673-61-7)
- Semaglutide impurity 274 (CAS CATO-C4X-2226274)
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