4-Cyano-6-(difluoromethyl)-2-methylnicotinic acid CAS 1805431-63-3
| CAS No. | 1805431-63-3 |
| Molecular Formula | C9H6F2N2O2 |
| Molecular Weight | 212.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-Cyano-6-(difluoromethyl)-2-methylnicotinic acid (CAS 1805431-63-3) is a high-purity analytical reference standard with the molecular formula C9H6F2N2O2 and a molecular weight of 212.15 g/mol.
The molecular framework of 4-Cyano-6-(difluoromethyl)-2-methylnicotinic acid (C9H6F2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 4-Cyano-6-(difluoromethyl)-2-methylnicotinic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H6F2N2O2 |
| Molecular Weight | 212.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Cyano Standards
- 6-Cyano-3-(difluoromethyl)-5-methylpicolinic acid (CAS 1804422-80-7)
- 4-Cyano-3-(difluoromethyl)-5-methoxypyridine-2-carboxaldehyde (CAS 1805424-51-4)
- 2-Cyano-3-(difluoromethyl)-5-methylisonicotinic acid (CAS 1805431-01-9)
- 2-Cyano-6-(difluoromethyl)-4-methylnicotinic acid (CAS 1805431-23-5)
- 2-(2-Cyano-3-(difluoromethyl)pyridin-4-yl)acetic acid (CAS 1806042-76-1)
- 4-Cyano-2-(difluoromethyl)pyridine-3-acetic acid (CAS 1806764-68-0)
- 6-Cyano-2-(difluoromethyl)-5-methylnicotinic acid (CAS 1806908-68-8)
- 4-Cyano-2-(difluoromethyl)-6-methoxypyridine-3-carboxaldehyde (CAS 1807085-26-2)
Recommended Standards
- 2-(Difluoromethyl)-5-formyl-3-methoxyisonicotinonitrile (CAS 1805926-34-4)
- 3-(Difluoromethyl)-5-formyl-2-methoxyisonicotinonitrile (CAS 1805926-37-7)
- 2-(Difluoromethyl)-6-formyl-3-methoxyisonicotinonitrile (CAS 1805390-44-6)
- 3-(Difluoromethyl)-2-formyl-6-methoxyisonicotinonitrile (CAS 1804730-24-2)
- 4-(Aminomethyl)-3-fluorobenzonitrile (CAS 701264-00-8)
- 4-Amino-N-ethyl-1H-imidazole-5-carboxamide (CAS 7253-70-5)
- 1-(Methylamino)cyclopentane-1-carboxylic acid hydrochloride (CAS 1609406-63-4)
- Methyl 5-((2-ethoxyphenyl)carbamoyl)-2-(2-fluorobenzamido)-4-methylthiophene-3-carboxylate (CAS 335410-33-8)
- Benzyl (S)-2-(2-aminoethyl)pyrrolidine-1-carboxylate (CAS 1932300-04-3)
- 2-(Dimethylamino)ethyl carbamate (CAS 4220-32-0)
- Ethyl 5-bromo-3-(trifluoromethyl)-2-pyridinecarboxylate (CAS 1214353-89-5)
- 2-((2,3-Dihydro-1H-inden-5-yl)amino)-2-oxoethyl 2-(methylthio)nicotinate (CAS 562800-17-3)
- 5-Bromo-2-(3,3-difluoropyrrolidin-1-yl)benzonitrile 1627693-40-6 (CAS 1627693-40-6)
- Insulin Degludec Impurity 10 (CAS CATO-C4X-215710)
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