4-(Difluoromethyl)-6-methoxy-2-methyl-3-(trifluoromethyl)pyridine CAS 1805433-32-2
| CAS No. | 1805433-32-2 |
| Molecular Formula | C9H8F5NO |
| Molecular Weight | 241.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Difluoromethyl)-6-methoxy-2-methyl-3-(trifluoromethyl)pyridine.
CATO supplies 4-(Difluoromethyl)-6-methoxy-2-methyl-3-(trifluoromethyl)pyridine (CAS 1805433-32-2), a certified reference material (molecular formula C9H8F5NO, MW 241.16 g/mol) for analytical method development and quality control.
Structurally, 4-(Difluoromethyl)-6-methoxy-2-methyl-3-(trifluoromethyl)pyridine (C9H8F5NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 241.16 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8F5NO |
| Molecular Weight | 241.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 4-(Difluoromethyl)-3-methoxy-2-methyl-6-(trifluoromethyl)pyridine (CAS 1805557-02-1)
- 4-(Difluoromethyl)-2-methoxy-5-methyl-3-(trifluoromethyl)pyridine (CAS 1806033-63-5)
- 4-(Difluoromethyl)-3-methoxy-2-methyl-5-(trifluoromethyl)pyridine (CAS 1806033-65-7)
- 4-(Difluoromethyl)-5-methoxy-3-methyl-2-(trifluoromethyl)pyridine (CAS 1806958-01-9)
- 4-(Difluoromethyl)-2-methoxy-3-methyl-5-(trifluoromethyl)pyridine (CAS 1807136-31-7)
- 2-(Difluoromethyl)-6-nitro-4H-chromen-4-one (CAS 380593-37-3)
- 5-(Difluoromethyl)-3-(4-nitrophenyl)-1,2,4-oxadiazole (CAS 866555-95-5)
- 2-[6-(Difluoromethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid (CAS 1855890-41-3)
Recommended Standards
- 5-(Aminomethyl)-3-(difluoromethyl)-6-(trifluoromethyl)pyridin-2-amine (CAS 1805362-52-0)
- 5-(Aminomethyl)-3-(difluoromethyl)-2-(trifluoromethyl)pyridin-4-amine (CAS 1805358-31-9)
- 3-(Aminomethyl)-6-(difluoromethyl)-5-(trifluoromethyl)pyridin-2-amine (CAS 1806004-91-0)
- 4-(Aminomethyl)-5-(difluoromethyl)-3-(trifluoromethyl)pyridin-2-amine (CAS 1805228-63-0)
- 2,2',2''-(Benzene-1,3,5-triyltris(ethyne-2,1-diyl))trianiline (CAS 1027340-24-4)
- 5-(1,1-Dimethylheptyl)resorcinol (CAS 56469-10-4)
- 841313-56-2 Diethoxybis[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]silane MFCD06246860 (CAS 841313-56-2)
- Gemfibrozil-d6 (2?2-dimethyl-d6) (CAS 1184986-45-5)
- N-(4-(Azepan-1-yl)but-2-yn-1-yl)benzo[d][1,3]dioxole-5-carboxamide (CAS 1396802-25-7)
- Bis(2-furoyltrifluoroacetonato)nickel(II) (CAS 14267-64-2)
- 1-(5-Bromo-3-fluoro-2-hydroxyphenyl)-2,2-dimethylpropan-1-one (CAS 1249909-74-7)
- 5-((3-(Butylcarbamoyl)phenyl)amino)-5-oxopentanoic acid (CAS 940536-60-7)
- (2R,3R)-1-ethyl-2-(4-methoxyphenyl)-6-oxopiperidine-3-carboxylic acid (CAS 1212189-30-4)
- Tetrapeptide-3 (CAS 827306-97-8)
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