2-(Difluoromethyl)-3-iodo-4-nitropyridine-5-sulfonamide CAS 1805542-86-2

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(Difluoromethyl)-3-iodo-4-nitropyridine-5-sulfonamide.

2-(Difluoromethyl)-3-iodo-4-nitropyridine-5-sulfonamide (CAS 1805542-86-2), molecular formula C6H4F2IN3O4S and molecular weight 379.08 g/mol, is a CATO reference standard with documented purity and traceability.

Owing to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/iodine substitution, an aromatic ring system, 2-(Difluoromethyl)-3-iodo-4-nitropyridine-5-sulfonamide is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 379.08 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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