2-(Difluoromethyl)-3-iodo-5-(trifluoromethyl)pyridine-6-carboxaldehyde CAS 1805552-89-9

Purity 97%+In StockPharmaceutical Standards
CAS No.1805552-89-9
Molecular FormulaC8H3F5INO
Molecular Weight351.01 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-(Difluoromethyl)-3-iodo-5-(trifluoromethyl)pyridine-6-carboxaldehyde CAS 1805552-89-9 chemical structure

Description

The occurrence of 2-(Difluoromethyl)-3-iodo-5-(trifluoromethyl)pyridine-6-carboxaldehyde is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

2-(Difluoromethyl)-3-iodo-5-(trifluoromethyl)pyridine-6-carboxaldehyde (CAS 1805552-89-9), molecular formula C8H3F5INO and molecular weight 351.01 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 2-(Difluoromethyl)-3-iodo-5-(trifluoromethyl)pyridine-6-carboxaldehyde (C8H3F5INO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC8H3F5INO
Molecular Weight351.01 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1995
Halogen ContentF/I-containing
Nitrogen Atoms1

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