2-Bromo-5-methylpyrimidin-4(3H)-one CAS 1805577-76-7
| CAS No. | 1805577-76-7 |
| Molecular Formula | C5H5BrN2O |
| Molecular Weight | 189.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Bromo-5-methylpyrimidin-4(3H)-one.
2-Bromo-5-methylpyrimidin-4(3H)-one (CAS 1805577-76-7) is a high-purity analytical reference standard with the molecular formula C5H5BrN2O and a molecular weight of 189.01 g/mol.
2-Bromo-5-methylpyrimidin-4(3H)-one (C5H5BrN2O) contains an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H5BrN2O |
| Molecular Weight | 189.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 5-Bromo-3-methylpyrazin-2-ol (CAS 100047-56-1)
- 2-Bromo-5-hydrazinylpyrazine (CAS 1001050-24-3)
- (4-bromo-1H-pyrazol-1-yl)acetaldehyde (CAS 1007550-84-6)
- 6-Bromo-2-methyl-3(2H)-pyridazinone (CAS 1123169-25-4)
- 2-Bromo-5-hydrazinylpyrimidine (CAS 1174413-61-6)
- 3-Bromo-1-methylpyrazin-2(1H)-one (CAS 1187017-25-9)
- 2-Bromo-5-methoxypyrimidine (CAS 1209459-99-3)
- 2-Bromo-3-methoxypyrazine (CAS 1209905-41-8)
Recommended Standards
- (6-Bromopyrimidin-4-yl)methanol (CAS 1805551-65-8)
- 5-Amino-6-bromopyridin-2-ol (CAS 1805620-31-8)
- 4-Bromo-6-methylpyrimidin-5-ol (CAS 1805505-33-2)
- 4-Bromo-2-hydroxy-6-methylpyrimidine (CAS 1806983-00-5)
- 4-Cyclopropoxy-5-isopropyl-N,N-dimethylpyridin-2-amine (CAS 1243456-80-5)
- tert-Butyl N-[3-isopropyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate (CAS 2377606-19-2)
- 3-(2-methyloxolan-2-yl)-1,2-oxazol-5-amine (CAS 1218915-67-3)
- 4-Fluoro-N-(pyridin-2-ylmethyl)-1,3-benzothiazol-2-amine (CAS 941867-13-6)
- 2-Chloro-N-(cyclopentylmethyl)acetamide (CAS 1096841-92-7)
- 4-Acetoxy-2-fluorobenzophenone (CAS 890099-40-8)
- 8-Amino-4-bromonaphthalen-1-ol (CAS 2167185-67-1)
- 2-(2-Chlorobenzyl)-5-methoxy-4,4-dimethylisoxazolidin-3-one (CAS 81777-97-1)
- 2,2,2-Trichloro-1-(4,5-dibromo-1H-pyrrol-2-yl)ethanone (CAS 50371-52-3)
- Semaglutide impurity 108 (CAS CATO-C4X-2226108)
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