2-(Aminomethyl)-6-(difluoromethyl)-5-methoxy-3-nitropyridine CAS 1805604-49-2
| CAS No. | 1805604-49-2 |
| Molecular Formula | C8H9F2N3O3 |
| Molecular Weight | 233.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Aminomethyl)-6-(difluoromethyl)-5-methoxy-3-nitropyridine (CAS 1805604-49-2), molecular formula C8H9F2N3O3 and molecular weight 233.17 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C8H9F2N3O3, 2-(Aminomethyl)-6-(difluoromethyl)-5-methoxy-3-nitropyridine contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 233.17 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9F2N3O3 |
| Molecular Weight | 233.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Aminomethyl Standards
- 2-(Aminomethyl)-3-(difluoromethyl)-5-methoxy-4-nitropyridine (CAS 1804870-01-6)
- 2-(Aminomethyl)-6-(difluoromethyl)-3-methoxy-5-nitropyridine (CAS 1805067-20-2)
- 2-(Aminomethyl)-4-(difluoromethyl)-6-methoxy-3-nitropyridine (CAS 1805442-13-0)
- 2-(Aminomethyl)-3-(difluoromethyl)-6-methoxy-4-nitropyridine (CAS 1805556-08-4)
- 2-(Aminomethyl)-3-(difluoromethyl)-4-methoxy-5-nitropyridine (CAS 1806957-75-4)
- 2-(Aminomethyl)-3-(difluoromethyl)-6-methoxy-5-nitropyridine (CAS 1806957-80-1)
- Methyl 5-(aminomethyl)-2-(trifluoromethyl)benzoate (CAS 1415206-84-6)
- Methyl 2-(aminomethyl)-5-(trifluoromethyl)benzoate (CAS 2122169-04-2)
Recommended Standards
- 2-(Difluoromethyl)-3-hydroxy-5-methoxypyridine-6-acetic acid (CAS 1805602-85-0)
- 4-(Difluoromethyl)-5,6-dimethoxynicotinic acid (CAS 1806046-27-4)
- 2-(Difluoromethyl)-3,5-dimethoxypyridine-4-carboxylic acid (CAS 1806800-35-0)
- 2-(Difluoromethyl)-5-hydroxy-3-methoxypyridine-6-acetic acid (CAS 1805537-71-6)
- 6-Methoxy-5-(prop-2-yn-1-ylamino)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide (CAS 2903923-10-2)
- 1-Bromo-2-chloro-4-methoxy-5-methylbenzene (CAS 502159-65-1)
- 1-(Piperazine-1-carbonyl)piperidine-3-carboxylic acid hydrochloride (CAS 1172442-08-8)
- 1’H-Spiro[piperidine-4,4’-quinazolin]-2’(3’H)-one (CAS 635713-68-7)
- (R)-2-(2,6-dichloro-3-fluorophenyl)pyrrolidine (CAS 1241681-81-1)
- 5-(2-Bromoacetyl)-5-methyldihydrofuran-2(3H)-one (CAS 67431-08-7)
- tert-Butyl 3-oxo-1-oxa-7-azaspiro[4.5]decane-7-carboxylate (CAS 1160246-89-8)
- 1-(2-Amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)propane-1,2-dione (CAS 89687-39-8)
- 3-(2-Methoxyethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (CAS 1707566-35-5)
- CGMP Dependent Kinase Inhibitor Peptide (CAS 82801-73-8)
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