4-(Difluoromethyl)-6-hydroxy-5-nitronicotinoyl chloride CAS 1805611-04-4
| CAS No. | 1805611-04-4 |
| Molecular Formula | C7H3ClF2N2O4 |
| Molecular Weight | 252.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Difluoromethyl)-6-hydroxy-5-nitronicotinoyl chloride.
4-(Difluoromethyl)-6-hydroxy-5-nitronicotinoyl chloride (CAS 1805611-04-4), molecular formula C7H3ClF2N2O4 and molecular weight 252.56 g/mol, is a CATO reference standard with documented purity and traceability.
4-(Difluoromethyl)-6-hydroxy-5-nitronicotinoyl chloride (C7H3ClF2N2O4) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(Difluoromethyl)-6-hydroxy-5-nitronicotinoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3ClF2N2O4 |
| Molecular Weight | 252.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-6-hydroxy-3-nitropyridine-5-carbonyl chloride (CAS 1804860-77-2)
- 2-(Difluoromethyl)-3-hydroxy-6-nitropyridine-5-carbonyl chloride (CAS 1805070-59-0)
- 2-(Difluoromethyl)-4-hydroxy-3-nitropyridine-5-carbonyl chloride (CAS 1805254-71-0)
- 2-(Difluoromethyl)-3-hydroxy-4-nitropyridine-6-carbonyl chloride (CAS 1805393-56-9)
- 2-(Difluoromethyl)-4-hydroxy-5-nitropyridine-3-carbonyl chloride (CAS 1805393-62-7)
- 2-(Difluoromethyl)-5-hydroxy-3-nitropyridine-4-carbonyl chloride (CAS 1805540-19-5)
- 2-(Difluoromethyl)-6-hydroxy-4-nitropyridine-3-carbonyl chloride (CAS 1805610-99-4)
- 4-(Difluoromethyl)-5-hydroxy-3-nitropicolinoyl chloride (CAS 1805611-10-2)
Recommended Standards
- 2-(Difluoromethyl)-6-hydroxy-3-nitropyridine-4-carbonyl chloride (CAS 1805617-79-1)
- 2-Chloro-6-(difluoromethyl)-4-nitronicotinic acid (CAS 1806872-45-6)
- 2-(Difluoromethyl)-4-hydroxy-6-nitropyridine-3-carbonyl chloride (CAS 1806884-96-7)
- 4-Chloro-2-(difluoromethyl)-5-nitronicotinic acid (CAS 1805271-65-1)
- 3-Amino-N-benzyl-N-(sec-butyl)propanamide (CAS 1178487-08-5)
- 1-Fluoro-3-(2-nitrovinyl)benzene (CAS 705-84-0)
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