2-(3-Bromopropyl)-3-(difluoromethoxy)toluene CAS 1805888-27-0
| CAS No. | 1805888-27-0 |
| Molecular Formula | C11H13BrF2O |
| Molecular Weight | 279.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(3-Bromopropyl)-3-(difluoromethoxy)toluene (CAS 1805888-27-0), molecular formula C11H13BrF2O and molecular weight 279.12 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(3-Bromopropyl)-3-(difluoromethoxy)toluene (C11H13BrF2O) is characterized by a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H13BrF2O |
| Molecular Weight | 279.12 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
Related Bromopropyl Standards
- 2-(3-Bromopropyl)-6-(difluoromethoxy)toluene (CAS 1805689-70-6)
- N-(3-Bromopropyl)benzenesulfonamide (CAS 3245-94-1)
- 1-(3-bromopropyl)-2,2,5,5-tetramethyl-1,2,5-azadisilolidine 1-Aza-1-(3-bromoprop-1-yl)-2,5-disila-2,2,5,5-tetramethylcyclopentane 95091-93-3 (CAS 95091-93-3)
- 1-(2-Bromopropyl)-4-(methylsulfonyl)benzene (CAS 1281623-93-5)
- 1-(2-Bromopropyl)-2-(methylsulfonyl)benzene (CAS 1409646-13-4)
- 1-((3-Bromopropyl)sulfonyl)-4-methylbenzene (CAS 5755-77-1)
- 7-(1-Bromopropyl)-5-chloro-2,3-dihydrobenzofuran (CAS 1566263-95-3)
- 4-(3-Bromopropyl)-1,1'-biphenyl (CAS 78733-59-2)
Recommended Standards
- 1-Bromo-2,4-difluoro-5-(3-methylbutoxy)benzene (CAS 1881293-88-4)
- 2-(Bromomethyl)-4-butoxy-1,3-difluorobenzene (CAS 1706446-25-4)
- 1-Bromo-3-butoxy-2,4-difluoro-5-methylbenzene (CAS 1881332-62-2)
- (4-(N,N-dimethylsulfamoyl)naphthalen-1-yl)boronic acid (CAS 1704097-52-8)
- 2-Amino-4-(2-ethyl-2H-tetrazol-5-yl)phenol (CAS 1020046-27-8)
- 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone (CAS 403811-55-2)
- 2-{[5-(furan-2-yl)-1,2-oxazol-3-yl]methoxy}acetic acid (CAS 1018165-66-6)
- Darunavir impurity 33 (CAS CATO-C4X-160633)
- 1-(4-Bromophenyl)-3-isobutylurea (CAS 195452-18-7)
- 5-Amino-2-chloro-4-fluorobenzonitrile (CAS 123614-87-9)
- Hexahydroindolizin-5(1H)-one (CAS 32537-55-6)
- 2-Methoxy-4-nitro-benzoic acid hydrazide (CAS 857599-45-2)
- Citalopram Impurity 70 (CAS 1332724-08-9)
- Semaglutide Impurity 147 (CAS CATO-C4X-2226147)
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