6-(Difluoromethyl)-2-hydroxy-3-(hydroxymethyl)isonicotinonitrile CAS 1805920-60-8
| CAS No. | 1805920-60-8 |
| Molecular Formula | C8H6F2N2O2 |
| Molecular Weight | 200.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 200.14 g/mol gives 6-(Difluoromethyl)-2-hydroxy-3-(hydroxymethyl)isonicotinonitrile distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
6-(Difluoromethyl)-2-hydroxy-3-(hydroxymethyl)isonicotinonitrile (CAS 1805920-60-8) is a high-purity analytical reference standard with the molecular formula C8H6F2N2O2 and a molecular weight of 200.14 g/mol.
Structurally, 6-(Difluoromethyl)-2-hydroxy-3-(hydroxymethyl)isonicotinonitrile (C8H6F2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 200.14 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-(Difluoromethyl)-2-hydroxy-3-(hydroxymethyl)isonicotinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6F2N2O2 |
| Molecular Weight | 200.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 4-(difluoromethyl)-3-methylisoxaZolo[5,4-b]pyridin-6(7h)-one (CAS 1018047-97-6)
- 3-(Difluoromethyl)-5-hydroxy-6-methoxypicolinonitrile (CAS 1804376-35-9)
- 2-(Difluoromethyl)-3,5-dihydroxypyridine-4-acetonitrile (CAS 1805006-12-5)
- 2-(Difluoromethyl)-3,6-dihydroxypyridine-5-acetonitrile (CAS 1805253-37-5)
- 2-(Difluoromethyl)-3,4-dihydroxypyridine-5-acetonitrile (CAS 1805253-48-8)
- 2-(Difluoromethyl)-4,6-dihydroxypyridine-3-acetonitrile (CAS 1805284-48-3)
- 2-(4-(Difluoromethyl)-3,6-dihydroxypyridin-2-yl)acetonitrile (CAS 1805284-52-9)
- 3-(Difluoromethyl)-6-hydroxy-2-(hydroxymethyl)isonicotinonitrile (CAS 1805287-61-9)
Recommended Standards
- 3-(Difluoromethyl)-5-hydroxy-2-(hydroxymethyl)isonicotinonitrile (CAS 1805427-21-7)
- 5-(Difluoromethoxy)benzo[d]oxazol-2-amine (CAS 1806532-29-5)
- 5-(Difluoromethyl)-4-hydroxy-3-methoxypicolinonitrile (CAS 1805420-50-1)
- 2-(4-(Difluoromethyl)-5,6-dihydroxypyridin-2-yl)acetonitrile (CAS 1806818-78-9)
- Ethyl 2-(thiazol-2-yl)pyrimidine-5-carboxylate (CAS 1068975-56-3)
- Methyl 5-amino-4-carbamoyl-1H-pyrazole-1-carboxylate (CAS 220131-61-3)
- 1-(2-Methoxy-5-methylphenyl)-3-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea (CAS 2096996-78-8)
- Vilanterol Impurity 85 (CAS CATO-C4X-193585)
- 2-((2-Ethoxyethyl)amino)acetonitrile (CAS 76753-37-2)
- Ganirelix(4-10)Impurity (CAS CATO-C4X-23732)
- 2-(2-Trifluoromethyl-benzoimidazol-1-yl)-propionic acid hydrochloride (CAS 1219422-80-6)
- Furfuryl-d5 Alcohol (CAS 1398065-62-7)
- 2-Methyl-6-(p-tolyl)imidazo[2,1-b][1,3,4]thiadiazole (CAS 57772-04-0)
- Acetyl tetrapeptide-3 (CAS 827306-88-7)
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