4-Cyano-2-(difluoromethyl)-3-iodo-6-(trifluoromethyl)pyridine CAS 1805922-04-6
| CAS No. | 1805922-04-6 |
| Molecular Formula | C8H2F5IN2 |
| Molecular Weight | 348.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
4-Cyano-2-(difluoromethyl)-3-iodo-6-(trifluoromethyl)pyridine (CAS 1805922-04-6), molecular formula C8H2F5IN2 and molecular weight 348.01 g/mol, is a CATO reference standard with documented purity and traceability.
4-Cyano-2-(difluoromethyl)-3-iodo-6-(trifluoromethyl)pyridine (C8H2F5IN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/iodine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H2F5IN2 |
| Molecular Weight | 348.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 2 |
Related Cyano Standards
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- 4-Cyano-N-(4-iodophenyl)benzamide (CAS 448200-86-0)
- 2-{[cyano(2,4-dichlorophenyl)methyl]sulfanyl}-4,6-dimethylpyridine-3-carbonitrile (CAS 477865-33-1)
- N-(2-Cyano-4-nitrophenyl)-2-((3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)thio)acetamide (CAS 750619-17-1)
- 2-Cyano-3-(4-methoxyphenyl)-N-(3-(trifluoromethyl)phenyl)propanamide (CAS 1261018-15-8)
- Methyl 5-cyano-2-methyl-6-(((3-phenylisoxazol-5-yl)methyl)amino)nicotinate (CAS 338749-65-8)
- 2-{[3-cyano-5-(ethoxycarbonyl)-4-(furan-2-yl)-6-methyl-1,4-dihydropyridin-2-yl]sulfanyl}acetic acid (CAS 852389-14-1)
- 4-Cyano-5-ethyl-3-(2-fluoro-[1,1-biphenyl]-4-yl)-1-methyl-1H-pyrrole-2-carboxylic acid (CAS 851196-32-2)
Recommended Standards
- 4-(Difluoromethyl)-3-iodo-6-(trifluoromethyl)picolinonitrile (CAS 1805387-25-0)
- 5-(Difluoromethyl)-4-iodo-3-(trifluoromethyl)picolinonitrile (CAS 1807078-12-1)
- 3-(Difluoromethyl)-5-iodo-4-(trifluoromethyl)picolinonitrile (CAS 1805387-18-1)
- 3-(Difluoromethyl)-5-iodo-2-(trifluoromethyl)isonicotinonitrile (CAS 1807095-63-1)
- 4-Chloro-6-(4-fluorophenyl)-[1,2,3]triazolo[1,5-a]pyrazine (CAS 1708428-31-2)
- 1-Cyclopentyl-1H-pyrazol-4-amine (CAS 1152866-89-1)
- 3-Formylbenzoic acid (CAS 619-21-6)
- tert-Butyl (3R)-3-amino-4,4-difluoropiperidine-1-carboxylate (CAS 2091351-96-9)
- 3,3-difluoro-5-nitro-2,3-dihydro-1H-indol-2-one (CAS 197067-34-8)
- Methyl (1-oxidopyridin-3-yl)acetate (CAS 2068782-90-9)
- Cochineal Carmine (CAS 15876-47-8)
- 2-Amino-3-phenyl-N-(tetrahydro-2-furanylmethyl)-propanamide hydrochloride (CAS 1236267-68-7)
- 1-(2-Chloropyridin-3-yl)ethan-1-amine (CAS 911825-90-6)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
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