3-(Difluoromethyl)-6-fluoro-2-methylpyridin-4-amine CAS 1805938-82-2
| CAS No. | 1805938-82-2 |
| Molecular Formula | C7H7F3N2 |
| Molecular Weight | 176.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(Difluoromethyl)-6-fluoro-2-methylpyridin-4-amine (CAS 1805938-82-2) is a high-purity analytical reference standard with the molecular formula C7H7F3N2 and a molecular weight of 176.14 g/mol.
Owing to a nitrile group, fluorine substitution, an aromatic ring system, 3-(Difluoromethyl)-6-fluoro-2-methylpyridin-4-amine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 176.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7F3N2 |
| Molecular Weight | 176.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 4-(Difluoromethyl)-3-fluoroanisole (CAS 1214329-92-6)
- 5-(Difluoromethyl)-2-fluoroanisole (CAS 1214333-36-4)
- 2-(Difluoromethyl)-5-fluoroanisole (CAS 1214338-95-0)
- 3-(Difluoromethyl)-4-fluoroanisole (CAS 1214353-02-2)
- 2-(Difluoromethyl)-3-fluoroanisole (CAS 1214358-22-1)
- 4-(Difluoromethyl)-2-fluoroanisole (CAS 1214364-97-2)
- 2-(Difluoromethyl)-4-fluoroanisole (CAS 1214379-81-3)
- 3-(Difluoromethyl)-5-(fluoromethyl)pyridin-4-amine (CAS 1803998-60-8)
Recommended Standards
- 3-(Difluoromethyl)-2-fluoro-6-methylpyridin-4-amine (CAS 1805938-81-1)
- 6-(Difluoromethyl)-3-(fluoromethyl)pyridin-2-amine (CAS 1806785-89-6)
- 2-(Difluoromethyl)-6-fluoro-3-methylpyridin-4-amine (CAS 1805938-80-0)
- 2-(Aminomethyl)-3-(difluoromethyl)-5-fluoropyridine (CAS 1806786-54-8)
- 1H-Benzo[d]pyrrolo[1,2-a]imidazole (CAS 247-76-7)
- 3-(sec-Butylamino)-1,1,1-trifluoro-2-propanol (CAS 477858-34-7)
- N,N-diethyl-2-(piperazin-1-yl)acetamide (CAS 40004-14-6)
- 2-Amino-N-(oxan-2-ylmethyl)ethane-1-sulfonamide hydrochloride (CAS 1306604-19-2)
- 6-(Hydroxymethyl)-1,2,4-triazine-3,5-diol (CAS 4449-45-0)
- Methyl 4-(((cyanomethyl)(ethyl)amino)methyl)benzoate (CAS 1308168-79-7)
- (3,6-Dichloropyridazin-4-yl)methanamine (CAS 871014-15-2)
- 2-Chloro-3-(difluoromethyl)-6-fluoropyridine-4-sulfonamide (CAS 1807041-52-6)
- 5-Amino-3-methyl-thiophene-2,4-dicarboxylic acid -4-ethyl ester 2-methyl ester (CAS 30823-51-9)
- Semaglutide impurity 76 (CAS CATO-C4X-222676)
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