2-(Bromomethyl)-6-cyano-4-(difluoromethyl)-3-nitropyridine CAS 1805973-74-3
| CAS No. | 1805973-74-3 |
| Molecular Formula | C8H4BrF2N3O2 |
| Molecular Weight | 292.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(Bromomethyl)-6-cyano-4-(difluoromethyl)-3-nitropyridine.
CATO supplies 2-(Bromomethyl)-6-cyano-4-(difluoromethyl)-3-nitropyridine (CAS 1805973-74-3), a certified reference material (molecular formula C8H4BrF2N3O2, MW 292.04 g/mol) for analytical method development and quality control.
The molecular framework of 2-(Bromomethyl)-6-cyano-4-(difluoromethyl)-3-nitropyridine (C8H4BrF2N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4BrF2N3O2 |
| Molecular Weight | 292.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 3 |
Related Bromomethyl Standards
- 2-(Bromomethyl)-3-cyano-6-(difluoromethyl)-5-nitropyridine (CAS 1805973-61-8)
- 2-(Bromomethyl)-4-cyano-3-(difluoromethyl)-5-nitropyridine (CAS 1806957-12-9)
- 2-(Bromomethyl)-6-cyano-5-(difluoromethyl)-3-nitropyridine (CAS 1807158-20-8)
- methyl 2-(bromomethyl)-3-fluoro-5-nitrobenzoate (CAS 2383631-75-0)
- Methyl 2-(bromomethyl)-5-fluoro-3-nitrobenzoate (CAS 850462-65-6)
- 1,2-Bis(bromomethyl)-4,5-dimethylbenzene (CAS 60070-06-6)
- 1,4-Bis(bromomethyl)-2,5-dimethylbenzene (CAS 35168-62-8)
- 3,5-Bis(bromomethyl)benzaldehyde (CAS 363622-51-9)
Recommended Standards
- 2-(4-Bromo-6-(difluoromethyl)-3-nitropyridin-2-yl)acetonitrile (CAS 1806914-01-1)
- 2-(6-Bromo-5-(difluoromethyl)-3-nitropyridin-2-yl)acetonitrile (CAS 1805443-44-0)
- 2-(6-Bromo-4-(difluoromethyl)-5-nitropyridin-3-yl)acetonitrile (CAS 1806922-26-8)
- 4-Bromo-2-(difluoromethyl)-3-nitropyridine-5-acetonitrile (CAS 1805379-79-6)
- Guanylyl-3-5-adenosine ammonium salt (CAS 103192-47-8)
- (R)-2-Amino-3,3-diphenylpropan-1-ol (CAS 171037-01-7)
- N-((1,2,3,4-tetrahydroquinolin-2-yl)methyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide (CAS 790153-34-3)
- 3-Chloro-2-methoxy-4-nitropyridine (CAS 1805648-70-7)
- methyl 2-[2-(2,2-dimethylhydrazin-1-yl)-1,3-thiazol-4-yl]acetate (CAS 1547541-48-9)
- 2-(2,2-Dimethyltetrahydro-2H-pyran-4-yl)ethan-1-amine (CAS 96822-36-5)
- ((tert-Butyl)amino)(4-(2-fluorophenyl)piperazinyl)methane-1-thione (CAS 1024126-83-7)
- 3-(1-Naphthoyl)quinolin-4(1H)-one (CAS 821004-09-5)
- 5-(4-Bromophenyl)-2-(isopropylthio)-1-methyl-1H-imidazole (CAS 1206989-96-9)
- MOTS-c Peptide (CAS 1627580-64-6)
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