2-(4-(Difluoromethyl)-5-fluoro-3-hydroxypyridin-2-yl)acetonitrile CAS 1805979-22-9

Purity 97%+In StockPharmaceutical Standards
CAS No.1805979-22-9
Molecular FormulaC8H5F3N2O
Molecular Weight202.13 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-(4-(Difluoromethyl)-5-fluoro-3-hydroxypyridin-2-yl)acetonitrile CAS 1805979-22-9 chemical structure

Description

CATO supplies 2-(4-(Difluoromethyl)-5-fluoro-3-hydroxypyridin-2-yl)acetonitrile (CAS 1805979-22-9), a certified reference material (molecular formula C8H5F3N2O, MW 202.13 g/mol) for analytical method development and quality control.

The molecular framework of 2-(4-(Difluoromethyl)-5-fluoro-3-hydroxypyridin-2-yl)acetonitrile (C8H5F3N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-(4-(Difluoromethyl)-5-fluoro-3-hydroxypyridin-2-yl)acetonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC8H5F3N2O
Molecular Weight202.13 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1995
Halogen ContentF-containing
Nitrogen Atoms2

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