4-(Difluoromethyl)-3-(hydroxymethyl)-5-(trifluoromethoxy)pyridin-2-ol CAS 1806048-70-3
| CAS No. | 1806048-70-3 |
| Molecular Formula | C8H6F5NO3 |
| Molecular Weight | 259.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 4-(Difluoromethyl)-3-(hydroxymethyl)-5-(trifluoromethoxy)pyridin-2-ol (CAS 1806048-70-3), a certified reference material (molecular formula C8H6F5NO3, MW 259.13 g/mol) for analytical method development and quality control.
Based on its molecular formula C8H6F5NO3, 4-(Difluoromethyl)-3-(hydroxymethyl)-5-(trifluoromethoxy)pyridin-2-ol contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 259.13 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6F5NO3 |
| Molecular Weight | 259.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 4-(Difluoromethyl)-3-methoxy-6-(trifluoromethoxy)pyridin-2-ol (CAS 1803695-86-4)
- 2-(Difluoromethyl)-5-hydroxy-3-methoxy-6-(trifluoromethoxy)pyridine (CAS 1803696-87-8)
- 2-(Difluoromethyl)-3-hydroxy-6-(trifluoromethoxy)pyridine-5-methanol (CAS 1804347-67-8)
- 2-(Difluoromethyl)-5-hydroxy-6-(trifluoromethoxy)pyridine-3-methanol (CAS 1804478-51-0)
- 2-(Difluoromethyl)-3-hydroxy-4-(trifluoromethoxy)pyridine-5-methanol (CAS 1804836-12-1)
- 4-(Difluoromethyl)-5-methoxy-6-(trifluoromethoxy)pyridin-2-ol (CAS 1806038-09-4)
- 4-(Difluoromethyl)-2-methoxy-6-(trifluoromethoxy)pyridin-3-ol (CAS 1806038-19-6)
- 2-(Difluoromethyl)-6-hydroxy-3-(trifluoromethoxy)pyridine-4-methanol (CAS 1806048-65-6)
Recommended Standards
- 2-(Difluoromethyl)-3-hydroxy-5-methoxy-6-(trifluoromethoxy)pyridine (CAS 1806266-38-5)
- 4-(Difluoromethyl)-5-methoxy-2-(trifluoromethoxy)pyridin-3-ol (CAS 1806266-74-9)
- 2-(Difluoromethyl)-4-hydroxy-6-(trifluoromethoxy)pyridine-3-methanol (CAS 1806727-58-1)
- 4-(Difluoromethyl)-2-(hydroxymethyl)-5-(trifluoromethoxy)pyridin-3-ol (CAS 1806727-78-5)
- Ethyl (methylsulfonyl)glycinate (CAS 88512-39-4)
- 3,3-Bis(methylthio)-1-(pyridin-2-yl)prop-2-en-1-one (CAS 78570-34-0)
- 2-(Carboxy(hydroxy)methyl)-6-methoxybenzo[d]oxazole (CAS 1806340-46-4)
- Hexanedioic-2,2,5,5-d4 Acid (CAS 19031-55-1)
- 3-Methyl-5-(5-methylisoxazol-3-yl)isoxazole-4-carboxylic acid (CAS 849066-63-3)
- Sodium 5,5'-((1E,1'E)-(2,2'-disulfo-[1,1'-biphenyl]-4,4'-diyl)bis(diazene-2,1-diyl))bis(2-oxidobenzoate) (CAS 6232-49-1)
- 2-Amino-3-(pyridin-3-yl)propan-1-ol (CAS 348619-81-8)
- tert-butyl N-[2-[3-[2-[2-[3-[[2-(tert-butoxycarbonylamino)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-2-oxo-ethyl]carbamate (CAS 2110448-96-7)
- Ethyl 1-(tert-butyl)-5-fluoro-1H-pyrazole-4-carboxylate (CAS 1269291-64-6)
- Tirzepatide Impurity 14 (CAS CATO-C4X-324014)
Why CATO?
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