3,5-Bis(trifluoromethyl)picolinonitrile CAS 1806530-83-5
| CAS No. | 1806530-83-5 |
| Molecular Formula | C8H2F6N2 |
| Molecular Weight | 240.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 3,5-Bis(trifluoromethyl)picolinonitrile (C8H2F6N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
3,5-Bis(trifluoromethyl)picolinonitrile (CAS 1806530-83-5) is a high-purity analytical reference standard with the molecular formula C8H2F6N2 and a molecular weight of 240.11 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3,5-Bis(trifluoromethyl)picolinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H2F6N2 |
| Molecular Weight | 240.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Bis Standards
- 4,5-Bis(trifluoromethyl)picolinonitrile (CAS 329711-41-3)
- {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid (CAS 146780-09-8)
- [4-(Trifluoromethyl)phenyl]methylphosphonic acid (CAS 146780-15-6)
- 1-(4-(Trifluoromethyl)pyrimidin-2-yl)-1h-1,2,4-triazole-3-carbonitrile (CAS 1197633-26-3)
- 5-(2-(Trifluoromethyl)phenyl)pyrimidin-2-ol (CAS 1111104-00-7)
- 3-[3-(trifluoromethyl)phenyl]-1h-pyrazole-4-carbaldehyde (CAS 1152541-77-9)
- 4-[3-(trifluoromethyl)-1h-pyrazol-1-yl]benzaldehyde (CAS 1172278-17-9)
- 2-(Trifluoromethyl)quinoline-4-carboxamide (CAS 1185292-59-4)
Recommended Standards
- 3-(Difluoromethyl)-5-fluoro-2-(trifluoromethyl)isonicotinonitrile (CAS 1805926-52-6)
- 3-(Difluoromethyl)-4-fluoro-6-(trifluoromethyl)picolinonitrile (CAS 1806950-12-8)
- 4-(Difluoromethyl)-6-fluoro-3-(trifluoromethyl)picolinonitrile (CAS 1805925-76-1)
- 4-(Difluoromethyl)-3-fluoro-5-(trifluoromethyl)picolinonitrile (CAS 1806950-18-4)
- ethyl 3-acetyl-4-oxocyclohexane-1-carboxylate (CAS 107861-64-3)
- Ethyl(4-ethylphenyl)sulfane (CAS 22905-10-8)
- 2-(2-Fluorobenzylidene)malononitrile (CAS 2698-43-3)
- 2-Amino-3-mercaptopropan-1-ol (CAS 584-01-0)
- 4-(Benzyloxy)phenylacetyl Chloride (CAS 39188-62-0)
- Tert-butyl 4-((3-bromophenyl)sulfonyl)-1,4-diazepane-1-carboxylate (CAS 1312440-85-9)
- Rubifolic acid (CAS 80489-65-2)
- n-Methyl-3-sulfamoylbenzamide (CAS 90271-48-0)
- 4-(4-chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-1H-imidazol-5-amine hydrochloride (CAS 1798002-54-6)
- Semaglutide impurity 203 (CAS CATO-C4X-2226203)
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