4-Chloro-2-cyano-6-(difluoromethyl)nicotinoyl chloride CAS 1806960-72-4
| CAS No. | 1806960-72-4 |
| Molecular Formula | C8H2Cl2F2N2O |
| Molecular Weight | 251.02 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-Chloro-2-cyano-6-(difluoromethyl)nicotinoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 4-Chloro-2-cyano-6-(difluoromethyl)nicotinoyl chloride (CAS 1806960-72-4), a certified reference material (molecular formula C8H2Cl2F2N2O, MW 251.02 g/mol) for analytical method development and quality control.
Based on its molecular formula C8H2Cl2F2N2O, 4-Chloro-2-cyano-6-(difluoromethyl)nicotinoyl chloride contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 251.02 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H2Cl2F2N2O |
| Molecular Weight | 251.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-5-cyano-6-(difluoromethyl)nicotinoyl chloride (CAS 1804669-56-4)
- 4-Chloro-2-cyano-5-(difluoromethyl)nicotinoyl chloride (CAS 1805056-15-8)
- 4-Chloro-3-cyano-5-(difluoromethyl)picolinoyl chloride (CAS 1805056-21-6)
- 4-Chloro-5-cyano-6-(difluoromethyl)picolinoyl chloride (CAS 1805362-51-9)
- 2-Chloro-5-cyano-4-(difluoromethyl)nicotinoyl chloride (CAS 1805980-70-4)
- 4-Chloro-6-cyano-5-(difluoromethyl)nicotinoyl chloride (CAS 1806960-67-7)
- 2-chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl chloride (CAS 154934-99-3)
- 2-(6-Chloro-5-(chloromethyl)-4-(difluoromethyl)pyridin-3-yl)acetonitrile (CAS 1804376-87-1)
Recommended Standards
- 2-Bromo-4,6-difluorobenzeneacetic acid (CAS 1807078-11-0)
- Methyl 4-Bromo-2,3-difluorobenzoate (CAS 1807244-07-0)
- 2-(2-Bromo-3,6-difluorophenyl)acetic acid (CAS 1805537-77-2)
- 3-Iodo-1-methyl-1H-pyrrole-2-carboxylic acid (CAS 1823935-30-3)
- (R)-4-Aminocyclopent-1-enecarboxylic acid (CAS 102629-74-3)
- 4-Chloro-1,3,6-trimethyl-1h-pyrazolo[3,4-d]pyrimidine (CAS 1484678-04-7)
- 2-Bromo-1-(pyrimidin-4-yl)ethanone hydrobromide (CAS 845267-57-4)
- 1-(2-Chloro-4-nitrophenyl)piperidine (CAS 55403-25-3)
- 2-(4-Chlorophenyl)-2-oxoethyl 2-(4-heptylphenyl)-8-methylquinoline-4-carboxylate (CAS 355433-26-0)
- Pentafluoroethane (CAS 354-33-6)
- 2-(4-(Morpholinomethyl)phenyl)acetic acid (CAS 521313-48-4)
- 7-(2-Hydroxyethyl)-9-phenylpyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-8(7H)-one (CAS 1158403-10-1)
- (1S)-[1,1'-Binaphthalene]-2,2'-disulfonyl dichloride (CAS 1226773-87-0)
- Semaglutide impurity 237 (CAS CATO-C4X-2226237)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com