3-(Difluoromethyl)-6-iodo-5-nitropicolinonitrile CAS 1806987-22-3
| CAS No. | 1806987-22-3 |
| Molecular Formula | C7H2F2IN3O2 |
| Molecular Weight | 325.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(Difluoromethyl)-6-iodo-5-nitropicolinonitrile.
CATO supplies 3-(Difluoromethyl)-6-iodo-5-nitropicolinonitrile (CAS 1806987-22-3), a certified reference material (molecular formula C7H2F2IN3O2, MW 325.01 g/mol) for analytical method development and quality control.
3-(Difluoromethyl)-6-iodo-5-nitropicolinonitrile (C7H2F2IN3O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/iodine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H2F2IN3O2 |
| Molecular Weight | 325.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 3 |
Related Difluoromethyl Standards
- 5-(Difluoromethyl)-2-iodo-3-nitroisonicotinonitrile (CAS 1805379-03-6)
- 3-(Difluoromethyl)-6-iodo-4-nitropicolinonitrile (CAS 1806856-58-5)
- 1-(Difluoromethyl)-3-iodo-5,6,7,8-tetrahydroquinolin-2(1H)-one (CAS 1707568-55-5)
- 3-({[4-(difluoromethyl)-6-methylpyrimidin-2-yl]sulfanyl}methyl)-4-methoxybenzaldehyde (CAS 438218-64-5)
- 2-(Difluoromethyl)-5-iodo-6-methoxypyridine-3-acetonitrile (CAS 1804862-25-6)
- 2-(4-(Difluoromethyl)-2-iodo-6-methoxypyridin-3-yl)acetonitrile (CAS 1805259-61-3)
- 2-(4-(Difluoromethyl)-5-iodo-2-methoxypyridin-3-yl)acetonitrile (CAS 1805259-67-9)
- 2-(6-(Difluoromethyl)-2-iodo-5-methoxypyridin-3-yl)acetonitrile (CAS 1805410-89-2)
Recommended Standards
- 2-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2096333-86-5)
- 4-(2-Bromoacetyl)phenylboronic Acid Pinacol Ester (CAS 908005-77-6)
- 4-Cyano-2-(difluoromethyl)-6-iodo-3-nitropyridine (CAS 1805378-92-0)
- 2-Fluoro-4,6-bis(trifluoromethyl)benzyl bromide (CAS 1017778-46-9)
- 5-Hydroxy-4-oxo-4H-chromene-3-carbaldehyde (CAS 153474-15-8)
- Sec-butyl (2R)-piperidine-2-carboxylate (CAS 1372901-82-0)
- 4-Amino-1-(3,3-bis(hydroxymethyl)cyclobutyl)pyrimidin-2(1H)-one (CAS 138420-50-5)
- 4-(5-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyrazin-2-yl)-6-(3,6-dihydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile (CAS CATO-C3D-262145)
- 2'-Chloro-4'-nitro-[1,1'-biphenyl]-3-carbaldehyde (CAS 1181385-58-9)
- (S)-3-Ethyl-4-methylpentan-1-ol (CAS 100431-87-6)
- 5-Cyclopropyl-4-iodo-1-methyl-1H-pyrazol-3-amine (CAS 1354706-78-7)
- (R)-6-(Aminomethyl)piperidin-2-one hydrochloride (CAS 2126143-91-5)
- 2-(5-Bromo-2-fluorophenyl)-5-chloro-1,3,4-thiadiazole (CAS 1342880-63-0)
- Semaglutide Impurity 9 (CAS CATO-C4X-22269)
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