2-(Bromomethyl)-3-cyano-6-(difluoromethyl)pyridine-4-acetonitrile CAS 1806995-65-2
| CAS No. | 1806995-65-2 |
| Molecular Formula | C10H6BrF2N3 |
| Molecular Weight | 286.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(Bromomethyl)-3-cyano-6-(difluoromethyl)pyridine-4-acetonitrile (CAS 1806995-65-2) is a high-purity analytical reference standard with the molecular formula C10H6BrF2N3 and a molecular weight of 286.08 g/mol.
The molecular framework of 2-(Bromomethyl)-3-cyano-6-(difluoromethyl)pyridine-4-acetonitrile (C10H6BrF2N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H6BrF2N3 |
| Molecular Weight | 286.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 3 |
Related Bromomethyl Standards
- 2-(4-(Bromomethyl)benzo[d]oxazol-2-yl)-2-hydroxyacetic acid (CAS 1804079-98-8)
- 2-(Bromomethyl)-5-cyano-4-(difluoromethyl)pyridine-3-acetonitrile (CAS 1805287-92-6)
- 2-(Bromomethyl)-3-cyano-4-(difluoromethyl)pyridine-5-acetonitrile (CAS 1805500-78-0)
- 2-(Bromomethyl)-6-cyano-3-(difluoromethyl)pyridine-4-acetonitrile (CAS 1807089-63-9)
- 2-(Bromomethyl)-6-cyano-3-(difluoromethyl)pyridine-5-acetonitrile (CAS 1807126-08-4)
- 2-[2-(Bromomethyl)phenyl]-2-(methoxyimino)acetic Acid Methyl Ester (CAS 115199-26-3)
- 121082-86-8 5-(Bromomethyl)-3-(4-methoxyphenyl)-1,3-oxazolidin-2-one DTXSID40569303 (CAS 121082-86-8)
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Recommended Standards
- (2,3-Difluoro-4-iodophenyl)(methyl)sulfane (CAS 2624417-88-3)
- Allyl 4-bromo-2-nitrobenzoate (CAS 1620682-38-3)
- (2,6-Difluoro-3-iodophenyl)(methyl)sulfane (CAS 2484889-05-4)
- Ethyl 2-bromo-8-hydroxyimidazo[1,2-b]pyridazine-7-carboxylate (CAS 1579103-55-1)
- 4-(4-Trifluoromethoxyphenyl)benzoic acid (CAS 728919-11-7)
- 2-(4-(Aminomethyl)-2-(difluoromethyl)-6-(trifluoromethyl)pyridin-3-yl)acetic acid (CAS 1361700-61-9)
- ethyl 2-[5-(hydroxymethyl)benzofuran-3-yl]acetate (CAS 2623103-04-6)
- 1-Ethyl-2,3-dimethyl-1H-indol-5-amine (CAS 883539-17-1)
- (6S)-6-Methyl-3-phenyl-1,4,5-oxathiazepane 4,4-dioxide (CAS 1537863-83-4)
- 3-Fluoro-4-methoxy-N-neopentylaniline (CAS 1247994-61-1)
- 1-(3,5-Bis(trifluoromethyl)phenyl)thiourea (CAS 175277-17-5)
- Ethyl 7-bromo-2H-benzo[d][1,2,3]triazole-5-carboxylate (CAS 1246759-55-6)
- 1-Acetyl-4-bromo-3-phenyl-5-(trifluoromethyl)-1H-pyrazole (CAS 1017793-50-8)
- Peptide 439 (CAS CATO-CPTD788439)
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