2-(Difluoromethyl)-3-hydroxy-6-methoxypyridine-5-acetonitrile CAS 1807002-64-7
| CAS No. | 1807002-64-7 |
| Molecular Formula | C9H8F2N2O2 |
| Molecular Weight | 214.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(Difluoromethyl)-3-hydroxy-6-methoxypyridine-5-acetonitrile.
CATO supplies 2-(Difluoromethyl)-3-hydroxy-6-methoxypyridine-5-acetonitrile (CAS 1807002-64-7), a certified reference material (molecular formula C9H8F2N2O2, MW 214.17 g/mol) for analytical method development and quality control.
2-(Difluoromethyl)-3-hydroxy-6-methoxypyridine-5-acetonitrile (C9H8F2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8F2N2O2 |
| Molecular Weight | 214.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 4-(Difluoromethyl)-5-(hydroxymethyl)-3-methoxypicolinonitrile (CAS 1804729-85-8)
- 2-(Difluoromethyl)-4-hydroxy-3-methoxypyridine-6-acetonitrile (CAS 1805061-47-5)
- 2-(4-(Difluoromethyl)-5-hydroxy-2-methoxypyridin-3-yl)acetonitrile (CAS 1805061-66-8)
- 2-(4-(Difluoromethyl)-2-hydroxy-5-methoxypyridin-3-yl)acetonitrile (CAS 1805204-41-4)
- 2-(Difluoromethyl)-6-hydroxy-4-methoxypyridine-3-acetonitrile (CAS 1805204-80-1)
- 2-(4-(Difluoromethyl)-3-hydroxy-5-methoxypyridin-2-yl)acetonitrile (CAS 1805251-52-8)
- 2-(4-(Difluoromethyl)-6-hydroxy-5-methoxypyridin-3-yl)acetonitrile (CAS 1805451-13-1)
- 2-(4-(Difluoromethyl)-6-hydroxy-5-methoxypyridin-2-yl)acetonitrile (CAS 1805535-42-5)
Recommended Standards
- 5-(Difluoromethyl)-4-(hydroxymethyl)-3-methoxypicolinonitrile (CAS 1806985-11-4)
- 2-(4-(Difluoromethyl)-6-hydroxy-3-methoxypyridin-2-yl)acetonitrile (CAS 1807002-97-6)
- 5-(Difluoromethyl)-3-(hydroxymethyl)-4-methoxypicolinonitrile (CAS 1806959-11-4)
- 3-(Difluoromethyl)-5-(hydroxymethyl)-4-methoxypicolinonitrile (CAS 1807104-31-9)
- 2-Amino-4-bromo-6-(trifluoromethyl)benzonitrile (CAS 1805022-91-6)
- 3-Isopropyl-N5,1-dimethyl-1H-pyrazole-4,5-diamine (CAS 169261-04-5)
- 9-iodonon-1-yne (CAS 87462-67-7)
- 2-Amino-6-hydroxyquinoline-3-carboxylic acid (CAS 157915-69-0)
- 3-Iodo-2-(trifluoromethylthio)pyridine (CAS 1204234-82-1)
- 1-(3-chloro-4-methyl-phenyl)hexahydropyrimidine-2,4-dione (CAS 949085-98-7)
- (S)-5-(2-Mercaptopropan-2-yl)imidazolidine-2,4-dione (CAS 77210-10-7)
- N-(2,4,6-trichlorophenyl)benzenesulfonamide (CAS 351027-75-3)
- (D-Trp8)-γ2-MSH trifluoroacetate salt (CAS 321351-81-9)
- Acetyl-(Leu28·31)-Neuropeptide Y (24-36) (CAS 155709-24-3)
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