2-(Chloromethyl)-5-(difluoromethyl)-6-fluoropyridine-3-acetic acid CAS 1807129-57-2
| CAS No. | 1807129-57-2 |
| Molecular Formula | C9H7ClF3NO2 |
| Molecular Weight | 253.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(Chloromethyl)-5-(difluoromethyl)-6-fluoropyridine-3-acetic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 2-(Chloromethyl)-5-(difluoromethyl)-6-fluoropyridine-3-acetic acid (CAS 1807129-57-2), a certified reference material (molecular formula C9H7ClF3NO2, MW 253.61 g/mol) for analytical method development and quality control.
2-(Chloromethyl)-5-(difluoromethyl)-6-fluoropyridine-3-acetic acid (C9H7ClF3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7ClF3NO2 |
| Molecular Weight | 253.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
- Methyl 6-(chloromethyl)-4-(trifluoromethyl)picolinate (CAS 1393543-87-7)
- Methyl 2-(chloromethyl)-6-(trifluoromethyl)isonicotinate (CAS 1393560-74-1)
- 2-(Chloromethyl)-6-(difluoromethyl)-4-fluoropyridine-3-acetic acid (CAS 1804380-14-0)
- 2-(Chloromethyl)-3-(difluoromethyl)-4-fluoropyridine-5-acetic acid (CAS 1805057-08-2)
- 2-(Chloromethyl)-3-(difluoromethyl)-5-fluoropyridine-6-acetic acid (CAS 1805446-03-0)
- 2-(Chloromethyl)-6-(difluoromethyl)-3-fluoropyridine-5-acetic acid (CAS 1806019-59-9)
- 2-(Chloromethyl)-5-(difluoromethyl)-3-fluoropyridine-6-acetic acid (CAS 1806880-55-6)
- 2-(Chloromethyl)-5-(difluoromethyl)-3-fluoropyridine-4-acetic acid (CAS 1806993-18-9)
Recommended Standards
- 2-(Chloromethyl)-6-(difluoromethyl)-5-fluoropyridine-3-acetic acid (CAS 1807069-22-2)
- 2-(Chloromethyl)-4-(difluoromethyl)-3-fluoropyridine-5-acetic acid (CAS 1807134-80-0)
- 2-(Chloromethyl)-3-(difluoromethyl)-4-fluoropyridine-6-acetic acid (CAS 1807069-00-6)
- 2-(Chloromethyl)-6-(difluoromethyl)-3-fluoropyridine-4-acetic acid (CAS 1807134-83-3)
- 3,3,5-Trimethylcyclohexane-1-sulfonyl chloride (CAS 1250496-80-0)
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- N-Isopropyl-5-methylpyridin-2-amine (CAS 1040341-22-7)
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