4-(Chloromethyl)-5-(difluoromethyl)-2-iodonicotinaldehyde CAS 1807153-96-3
| CAS No. | 1807153-96-3 |
| Molecular Formula | C8H5ClF2INO |
| Molecular Weight | 331.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
4-(Chloromethyl)-5-(difluoromethyl)-2-iodonicotinaldehyde (CAS 1807153-96-3), molecular formula C8H5ClF2INO and molecular weight 331.49 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Chloromethyl)-5-(difluoromethyl)-2-iodonicotinaldehyde (C8H5ClF2INO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2INO |
| Molecular Weight | 331.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl/I-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
- 2-(Chloromethyl)-5-(difluoromethyl)-6-iodopyridine-3-carboxaldehyde (CAS 1805067-09-7)
- 2-(Chloromethyl)-4-(difluoromethyl)-5-iodopyridine-3-carboxaldehyde (CAS 1805621-71-9)
- 2-(Chloromethyl)-6-(difluoromethyl)-5-iodopyridine-3-carboxaldehyde (CAS 1805621-77-5)
- 2-(Chloromethyl)-3-(difluoromethyl)-6-iodopyridine-4-carboxaldehyde (CAS 1806956-34-2)
- 2-(Chloromethyl)-6-(difluoromethyl)-4-iodopyridine-3-carboxaldehyde (CAS 1807103-19-0)
- 2-(Chloromethyl)-3-(difluoromethyl)-5-iodopyridine-6-carboxaldehyde (CAS 1807153-39-4)
- 4-(Chloromethyl)-N-(3-chlorophenyl)-3-(3-methoxypropyl)thiazol-2(3h)-imine (CAS 721418-94-6)
- 4-(5-(Chloromethyl)-1,2,4-oxadiazol-3-yl)-N-((5-methylfuran-2-yl)methyl)benzamide (CAS 1119452-10-6)
Recommended Standards
- 7, 8 : 15, 16-Dibenzoterrylene (CAS 187-96-2)
- 2-(Difluoromethyl)-5-iodo-3-methylpyridine-4-carbonyl chloride (CAS 1807139-20-3)
- 1-(4-Nonylbenzyl)pyrrolidine-3-carboxylic acid (CAS 570423-46-0)
- 2-(Difluoromethyl)-3-iodo-5-methylpyridine-4-carbonyl chloride (CAS 1807139-12-3)
- 4-Chlorobenzyl isothiocyanate (CAS 3694-45-9)
- 1-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline (CAS 338793-09-2)
- (4-(Thiophen-2-yl)phenyl)methanol (CAS 16939-04-1)
- 3-Chloro-N,4-dimethylaniline, HCl (CAS 7745-94-0)
- 3-(Piperidin-4-yl)pyrazin-2-ol (CAS 1520924-70-2)
- Benzoic acid, 2-propen-1-yl ester, polymer with ethenylbenzene and 2-propen-1-ol (CAS 70776-41-9)
- 2-(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)-2-oxoacetic acid (CAS 1644503-10-5)
- 1-(Hydroxymethyl)-1,3,5-triazinane-2,4,6-trione (CAS 90031-15-5)
- 4-(3-bromothiophen-2-yl)-2-chloropyrimidine (CAS 1513145-66-8)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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