2-(4-Cyano-3-(difluoromethoxy)-2-ethylphenyl)acetic acid CAS 1807216-89-2
| CAS No. | 1807216-89-2 |
| Molecular Formula | C12H11F2NO3 |
| Molecular Weight | 255.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(4-Cyano-3-(difluoromethoxy)-2-ethylphenyl)acetic acid (CAS 1807216-89-2) is a high-purity analytical reference standard with the molecular formula C12H11F2NO3 and a molecular weight of 255.22 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 2-(4-Cyano-3-(difluoromethoxy)-2-ethylphenyl)acetic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 255.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(4-Cyano-3-(difluoromethoxy)-2-ethylphenyl)acetic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H11F2NO3 |
| Molecular Weight | 255.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Cyano Standards
- 2-(2-Cyano-4-(difluoromethoxy)-3-ethylphenyl)acetic acid (CAS 1805627-59-1)
- 2-(2-Cyano-3-(difluoromethoxy)-4-ethylphenyl)acetic acid (CAS 1805662-08-1)
- 2-(4-Cyano-2-(difluoromethoxy)-5-ethylphenyl)acetic acid (CAS 1805662-49-0)
- 2-(4-Cyano-2-(difluoromethoxy)-3-ethylphenyl)acetic acid (CAS 1805664-31-6)
- 4-Cyano-1-cyclohexen-1-yl 1,1,1-Trifluoro-methanesulfonate (CAS 1435805-92-7)
- 3'-Cyano-2'-fluoro-2-methyl-[1,1'-biphenyl]-4-carboxylic acid (CAS 1261923-39-0)
- 5'-Cyano-2'-fluoro-2-methyl-[1,1'-biphenyl]-4-carboxylic acid (CAS 1262006-23-4)
- Methyl 3'-cyano-3-fluoro-[1,1'-biphenyl]-4-carboxylate (CAS 1365272-67-8)
Recommended Standards
- Methyl 1-(3,4-difluorophenyl)-5-oxopyrrolidine-3-carboxylate (CAS 1820604-85-0)
- (R)-2-((((Benzyloxy)carbonyl)amino)oxy)-3-hydroxypropanoic acid (CAS 2767028-97-5)
- 1-(2,6-Difluorobenzyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 304859-20-9)
- 2,2'-((2,4-Dihydroxybenzyl)azanediyl)diacetic acid (CAS 337493-89-7)
- 2,4-Dichloro-N-propylbenzenesulfonamide (CAS 328062-40-4)
- 2-(4-Benzoylbenzamido)acetic acid (CAS 53053-10-4)
- 6-(Dimethylamino)-1-methyl-3-propyl-1,3,5-triazine-2,4(1H,3H)-dione (CAS 51235-42-8)
- (4-Morpholinoquinolin-2-yl)boronic acid (CAS 1201845-56-8)
- 1-[4-(Dimethylamino)-2-hydroxyphenyl]ethan-1-one (CAS 107070-69-9)
- 2,6-Dimethylbenzonitrile (CAS 6575-13-9)
- N~1~-Benzyl-N~1~,4-dimethyl-1,2-benzenediamine (CAS 1097786-19-0)
- (S)-2-(5-fluoropyridin-2-yl)-4-isopropyl-4,5-dihydrooxazole (CAS 2757083-15-9)
- 2-(3-Chloro-2-(hydroxymethyl)phenyl)-6-cyclopropyl-8-fluoroisoquinolin-1(2H)-one, 97% (CAS 1242156-55-3)
- Exenatide (CAS 141758-74-9（free base）)
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