2,5-Difluoro-3,4-dimethoxybenzaldehyde CAS 181776-02-3
| CAS No. | 181776-02-3 |
| Molecular Formula | C9H8F2O3 |
| Molecular Weight | 202.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2,5-Difluoro-3,4-dimethoxybenzaldehyde (CAS 181776-02-3), molecular formula C9H8F2O3 and molecular weight 202.15 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2,5-Difluoro-3,4-dimethoxybenzaldehyde is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 202.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 2,5-Difluoro-3,4-dimethoxybenzaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8F2O3 |
| Molecular Weight | 202.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | F-containing |
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Recommended Standards
- 5-Difluoromethoxy-2-methoxybenzaldehyde (CAS 1806377-15-0)
- 3,4-Difluoro-2-methoxy-5-methylbenzoic acid (CAS 1824083-96-6)
- Methyl 3,4-difluoro-5-methoxybenzoate (CAS 1806332-46-6)
- 2-(2-(Difluoromethyl)phenoxy)acetic acid (CAS 1889400-31-0)
- 2-(4-Methoxyphenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one (CAS 77779-50-1)
- Ethyl 4-methyl-2-(3-(trifluoromethyl)phenyl)thiazole-5-carboxylate (CAS 144061-14-3)
- 3-((4-Methylpiperidin-1-yl)methyl)benzaldehyde (CAS 1443323-34-9)
- 3-amino-1-(propan-2-yl)pyrrolidine-2,5-dione hydrochloride (CAS 1375471-37-6)
- ((2,3,5,6-Tetramethylphenyl)sulfonyl)glycine (CAS 379250-94-9)
- Tert-butyl (1R,5S)-3-thia-7-azabicyclo[3.3.1]Nonane-9-carboxylate 3,3-dioxide (CAS 1691197-39-3)
- 1,3-Butadiene-1,1,4,4-d4 (gas) (stabilized with hydroquinone) (CAS 10545-58-1)
- 2,4-Dichloro-7-fluoroquinazoline (CAS 174566-15-5)
- (2-Fluorophenyl)(2-methylpyridin-4-yl)methanone (CAS 1187167-17-4)
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