rac-(1R,2R)-2-(5-bromothiophen-3-yl)cyclopropane-1-carboxylic acid CAS 1818258-14-8
| CAS No. | 1818258-14-8 |
| Molecular Formula | C8H7BrO2S |
| Molecular Weight | 247.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies rac-(1R,2R)-2-(5-bromothiophen-3-yl)cyclopropane-1-carboxylic acid (CAS 1818258-14-8), a certified reference material (molecular formula C8H7BrO2S, MW 247.11 g/mol) for analytical method development and quality control.
The molecular framework of rac-(1R,2R)-2-(5-bromothiophen-3-yl)cyclopropane-1-carboxylic acid (C8H7BrO2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7BrO2S |
| Molecular Weight | 247.11 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Br-containing |
| Sulfur Atoms | 1 |
Recommended Standards
- (1S,2S)-rel-2-(5-Bromothiophen-2-yl)cyclopropane-1-carboxylic acid (CAS 1818257-71-4)
- Bromo-PEG2-MS (CAS 1935075-34-5)
- (1R,2R)-2-(4-Bromothiophen-2-yl)cyclopropane-1-carboxylic acid (CAS 1818257-30-5)
- (4-Bromo-phenylsulfanyl)-acetic acid (CAS 3406-76-6)
- ((4-Chlorophenoxy)methyl)triphenylphosphonium chloride (CAS 69743-39-1)
- 1,3-Bis[2,6-bis(1-methylethyl)phenyl]-2,2-difluoro-2,3-dihydro-1H-imidazole (CAS 1314657-40-3)
- 6-Bromo-2-chloronicotinonitrile (CAS 1171919-79-1)
- 5-[(2-Hydroxyphenyl)amino]-5-oxopentanoic acid (CAS 477307-73-6)
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