N-(2-((4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide CAS 1818339-66-0
| CAS No. | 1818339-66-0 |
| Molecular Formula | C18H19F2N5O3S2 |
| Molecular Weight | 455.50 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
N-(2-((4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide (CAS 1818339-66-0), molecular formula C18H19F2N5O3S2 and molecular weight 455.50 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(2-((4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide (C18H19F2N5O3S2) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H19F2N5O3S2 |
| Molecular Weight | 455.50 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 2 |
Recommended Standards
- Z-Val-Gly-Phe-OH (C-2860.1000) (CAS 138867-42-2)
- 3-((4-Methylbenzyl)thio)-4-phenyl-5-((3-(trifluoromethyl)phenoxy)methyl)-4H-1,2,4-triazole (CAS 383145-78-6)
- N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(1S)-2,2-dimethyl-1-(1-piperidinylmethyl)propyl]thiourea (CAS 1260435-12-8)
- Z-Val-Gly-Gly-OBzl (C-2855.0005) (CAS 72722-19-1)
- Methyl 3-chloro-5-fluoro-2-methoxybenzoate (CAS 2105066-17-7)
- Tert-butyl 2-(1H-indol-5-yl)pyrrolidine-1-carboxylate (CAS 1355182-61-4)
- (R)-4-(3-Methoxyphenyl)pyrrolidin-2-one hydrochloride (CAS 1384268-74-9)
- Allylestrenol Impurity 1 (CAS 3646-28-4)
- 6-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (CAS 1256358-98-1)
- 2-(2-Aminoethyl)-6-phenyl-4,5-dihydropyridazin-3(2H)-one hydrochloride (CAS 1269288-52-9)
- 6'-Chlorospiro[cyclobutane-1,3'-indoline] (CAS 1403899-03-5)
- 3-Cyclopentyl-1-methyl-1H-pyrazole hydrochloride (CAS 2137851-34-2)
- Diethyl 2-(((2-(methoxycarbonyl)thiophen-3-yl)amino)methylene)malonate (CAS 74695-17-3)
- Semaglutide Impurity 149 (CAS CATO-C4X-2226149)
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