4-[(3,3-difluoroazetidin-1-yl)methyl]aniline CAS 1818412-11-1
| CAS No. | 1818412-11-1 |
| Molecular Formula | C10H18F2N2 |
| Molecular Weight | 204.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-[(3,3-difluoroazetidin-1-yl)methyl]aniline is closely related to a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-[(3,3-difluoroazetidin-1-yl)methyl]aniline (CAS 1818412-11-1), molecular formula C10H18F2N2 and molecular weight 204.26 g/mol, is a CATO reference standard with documented purity and traceability.
4-[(3,3-difluoroazetidin-1-yl)methyl]aniline (C10H18F2N2) contains a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-[(3,3-difluoroazetidin-1-yl)methyl]aniline under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H18F2N2 |
| Molecular Weight | 204.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related difluoroazetidin Standards
- 5-(3,3-Difluoroazetidin-1-yl)-1H-indole (CAS 1707706-75-9)
- 5-(3,3-Difluoroazetidin-1-yl)picolinaldehyde (CAS 1707581-14-3)
- 2-(3,3-Difluoroazetidin-1-yl)nicotinaldehyde (CAS 1707605-02-4)
- 3-(3,3-Difluoroazetidin-1-yl)isonicotinaldehyde (CAS 1774895-44-1)
- 5-(3,3-Difluoroazetidin-1-yl)nicotinaldehyde (CAS 1774895-47-4)
- 3-(3,3-Difluoroazetidin-1-yl)picolinaldehyde (CAS 1774895-80-5)
- 2-(3,3-Difluoroazetidin-1-yl)-3-nitropyridine 1713162-86-7 (CAS 1713162-86-7)
- 3-(3,3-Difluoroazetidin-1-yl)-2-nitropyridine (CAS 1779124-76-3)
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