6-Chloro-5-fluoro-2-methoxynicotinonitrile CAS 1820650-64-3
| CAS No. | 1820650-64-3 |
| Molecular Formula | C7H4ClFN2O |
| Molecular Weight | 186.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 6-Chloro-5-fluoro-2-methoxynicotinonitrile (CAS 1820650-64-3), a certified reference material (molecular formula C7H4ClFN2O, MW 186.57 g/mol) for analytical method development and quality control.
The molecular framework of 6-Chloro-5-fluoro-2-methoxynicotinonitrile (C7H4ClFN2O) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 6-Chloro-5-fluoro-2-methoxynicotinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4ClFN2O |
| Molecular Weight | 186.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 6-Chloro-2-fluoro-8-methyl-9H-purine (CAS 1060816-70-7)
- 5-Chloro-6-fluoro-2,3-dihydro-1h-1,3-benzodiazol-2-one (CAS 1075753-25-1)
- 4-Chloro-6-fluoro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (CAS 1190316-86-9)
- 5-Chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (CAS 1190318-22-9)
- 6-Chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (CAS 1190321-07-3)
- 6-Chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (CAS 1190322-06-5)
- 5-Chloro-7-fluoro-1H-indazol-3(2H)-one (CAS 1227271-00-2)
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Recommended Standards
- 6-Chloro-5-fluorobenzo[d]oxazol-2-amine (CAS 1268032-07-0)
- 7-Chloro-6-fluoro-1,3-benzoxazol-2-amine (CAS 1820711-05-4)
- 3-Chloro-5-(fluoromethoxy)picolinonitrile (CAS 1262860-71-8)
- 7-Chloro-5-fluoroisobenzofuran-1(3H)-one (CAS 1823931-26-5)
- ((2R,3R,4S,5R)-3-(Benzoyloxy)-4-fluoro-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate (CAS 952651-49-9)
- epi-Lactose (CAS 50468-56-9)
- 4-Bromo-3-methyl-6-(trifluoromethyl)-1H-indole (CAS 1360893-22-6)
- Methyl 3-(2,3-dihydroxypropoxy)benzoate (CAS 67032-33-1)
- 3-(Cyclopropylmethyl)-1,2,4-thiadiazol-5-amine (CAS 1538401-81-8)
- Pravastatin EP Impurity A Sodium Salt (CAS 81176-41-2)
- 5-Methyl-3-nitropicolinaldehyde (CAS 52381-07-4)
- Glycidyl Palmitate (CAS 7501-44-2)
- N-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-5-phenyloxazole-2-carboxamide (CAS 955769-02-5)
- Semaglutide impurity 61 (CAS CATO-C4X-222661)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com